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genomics lab

Lubov Nathanson, Ph.D.

Dr Lubov Nathanson headshot

Associate Professor, Director, Genomics Group, Institute for Neuro Immune Medicine, Dr. Kiran C. Patel College of Osteopathic Medicine, Nova Southeastern University

Lubov Nathanson, Ph.D. is an Associate Professor at Nova Southeastern University (NSU), where her research efforts focus on translational genomics. Her combined expertise in bioinformatics, molecular biology, biochemistry, and systems biology allows her to evaluate complex disease states that impact multiple organ systems and have complicated mechanisms of disease onset, activity, and progression. Her current research efforts focus on gaining insight into the epigenomic and transcriptional changes involved in multi-symptom disorders including Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) and Gulf War illness (GWI). Specifically, her ongoing research involves identifying biomarkers and mechanisms of ME/CFS and GWI using approaches such as RNA-seq, Copy Number Variation and DNA methylation to identify transcriptional regulators that result in characteristic symptomatology associated with ME/CFS and GWI.

Prior to Dr. Nathanson’s faculty appointment at NSU, she earned her Ph.D. in Molecular Biology and Biochemistry from the prestigious Weizmann Institute of Science in Israel and completed her post-doctoral work at the University of Miami Miller School of Medicine, where she built her expertise in cellular processes. As a manager and later Director of the Gene Expression and Microarray Core (2004 - 2010), she gained extensive hands-on experience of sample processing for microarray, NanoString and Next Generation Sequencing analyses. As part of the Bioinformatics group (2010-2012) Dr. Nathanson utilized extensive bioinformatics software tools. She also gained experience in analyzing large genomics datasets as well as conducting systems biology analyses. Thus, she has combined expertise in bioinformatics, Molecular Biology, Biochemistry and Systems Biology to understand the underlying mechanism of complex disease states. Much of her academic work in recent years involved analyses of gene expression data from NanoString, microarrays and RNA-seq (see publications).

W81XWH-20-GWIRP-RAA, DoD USAMRAA
Nathanson (PI)
09/30/2021-09/29/2024
Immune dysregulation in GWI

W81XWH-18-1-0660, DoD USAMRAA
Nathanson (PI)
09/30/2018-09/29/2022
Immunomodulation in GWI

R15 NS087604-01A1, National Institute of Neurological Disorders and Stroke (NINDS)
Nathanson (PI)
04/15/2015-03/31/2019
Genomic approach to find novel biomarkers and mechanisms of CFS/ME

R21 AI124187-01, National Institute of Allergy and Infectious Diseases (NIAID)
Nathanson (PI)
04/06/2016-03/31/2019
Sex-specific genomic mechanisms of transcriptional regulation in ME/CFS/SEID

1. Van Booven DJ, Gamer J, Joseph A, Perez M, Zarnowski O, Pandya M, Collado F, Klimas N, Oltra E, Nathanson L. Stress-Induced Transcriptomic Changes in Females with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Reveal Disrupted Immune Signatures. Int J Mol Sci. 2023 Jan 31;24(3):2698. doi: 10.3390/ijms24032698. PMID: 36769022; PMCID: PMC9916639.

2. Gamer J, Van Booven DJ, Zarnowski O, Arango S, Elias M, Kurian A, Joseph A, Perez M, Collado F, Klimas N, Oltra E, Nathanson L. Sex-Dependent Transcriptional Changes in Response to Stress in Patients with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: A Pilot Project. Int J Mol Sci. 2023 Jun 17;24(12):10255. doi: 10.3390/ijms241210255. PMID: 37373402; PMCID: PMC10299261.

3. Ho A, Ngala B, Yamada C, Garcia C, Duarte C, Akkaoui J, Ciolac D, Nusbaum A, Kochen W, Efremova D, Groppa S, Nathanson L, Bissel S, Oblak A, Kacena MA, Movila A. IL-34 exacerbates pathogenic features of Alzheimer's disease and calvaria osteolysis in triple transgenic (3x-Tg) female mice. Biomed Pharmacother. 2023 Oct;166:115435. doi: 10.1016/j.biopha.2023.115435. Epub 2023 Sep 4. PMID: 37666180; PMCID: PMC10710767.

4. Addanki S, Patel K, Patel L, Smith B, Patel P, Uppalapati S, Nathanson L. Thyroid Function and Sleep Patterns: A Systematic Review. Cureus. 2024 Jun 29;16(6):e63447. doi: 10.7759/cureus.63447. PMID: 39077291; PMCID: PMC11285688.

1. Dr. Nathanson’s earlier research contributed to the understanding of the structure and function of the protein synthesis apparatus in mammalian cells. Publications from this period showed significance of the protein complexes and their interaction with the cytoskeleton in the mammalian cells.

  1. Hudder A, Nathanson L, Deutscher MP. Organization of mammalian cytoplasm. Mol Cell Biol. 2003 Dec;23(24):9318-26. PubMed PMID: 14645541; PubMed Central PMCID: PMC309675.
  2. Nathanson L, Xia T, Deutscher MP. Nuclear protein synthesis: a re-evaluation. RNA. 2003 Jan;9(1):9-13. PubMed PMID: 12554870; PubMed Central PMCID: PMC1370364.
  3. Nathanson L, Deutscher MP. Active aminoacyl-tRNA synthetases are present in nuclei as a high molecular weight multienzyme complex. J Biol Chem. 2000 Oct 13;275(41):31559-62. PubMed PMID: 10930398.

2. Dr. Nathanson was actively involved in the projects that investigated development of cancer and helped to evaluate the effects of anti-cancer drugs.

  1. Zhang M, Ceyhan Y, Kaftanovskaya EM, Vasquez JL, Vacher J, Knop FK, Nathanson L, Agoulnik AI, Ittmann MM, Agoulnik IU. INPP4B protects from metabolic syndrome and associated disorders. Commun Biol. 2021 Mar 26;4(1):416. doi: 10.1038/s42003-021-01940-6. PMID: 33772116; PMCID: PMC7998001.
  2. Zhang M, Suarez E, Vasquez JL, Nathanson L, Peterson LE, Rajapakshe K, Basil P, Weigel NL, Coarfa C, Agoulnik IU. Inositol polyphosphate 4-phosphatase type II regulation of androgen receptor activity. Oncogene. 2019 Feb;38(7):1121-1135. PubMed PMID: 30228349; PubMed Central PMCID: PMC6377303.
  3. Ramachandran K, Speer C, Nathanson L, Claros M, Singal R. Role of DNA Methylation in Cabazitaxel Resistance in Prostate Cancer. Anticancer Res. 2016 Jan;36(1):161-8. PubMed PMID: 26722040.
  4. Subbarayan PR, Sarkar M, Nathanson L, Doshi N, Lokeshwar BL, Ardalan B. In Vitro Global Gene Expression Analyses Support the Ethnopharmacological Use of Achyranthes aspera. Evid Based Complement Alternat Med. 2013;2013:471739. PubMed PMID: 24454496; PubMed Central PMCID: PMC3880711.

3. As a manager, and later as a Director of the Microarray and Gene Expression Core, Dr. Nathanson participated in multiple projects and was responsible for the analysis of the large genomic datasets.

  1. Humphries CE, Kohli MA, Nathanson L, Whitehead P, Beecham G, Martin E, Mash DC, Pericak-Vance MA, Gilbert J. Integrated whole transcriptome and DNA methylation analysis identifies gene networks specific to late-onset Alzheimer's disease. J Alzheimers Dis. 2015;44(3):977-87. PubMed PMID: 25380588.
  2. McElroy JP, Krupp LB, Johnson BA, McCauley JL, Qi Z, Caillier SJ, Gourraud PA, Yu J, Nathanson L, Belman AL, Hauser SL, Waubant E, Hedges DJ, Oksenberg JR. Copy number variation in pediatric multiple sclerosis. Mult Scler. 2013 Jul;19(8):1014-21. PubMed PMID: 23239789; PubMed Central PMCID: PMC5507577.
  3. Hedges DJ, Hamilton-Nelson KL, Sacharow SJ, Nations L, Beecham GW, Kozhekbaeva ZM, Butler BL, Cukier HN, Whitehead PL, Ma D, Jaworski JM, Nathanson L, Lee JM, Hauser SL, Oksenberg JR, Cuccaro ML, Haines JL, Gilbert JR, Pericak-Vance MA. Evidence of novel fine-scale structural variation at autism spectrum disorder candidate loci. Mol Autism. 2012 Apr 2;3:2. PubMed PMID: 22472195; PubMed Central PMCID: PMC3352055.

4. Lately Dr. Nathanson has led the transcriptomic and epigenetic research of our group to find new diagnostic and therapeutic strategies for the multi symptoms diseases such as Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) and Gulf War Illness (GWI). The group has characterized for the first time transcriptomic and genome-wide epigenetic changes associated with multi-symptom disorders. In collaboration with Dr. Oltra from the Catholic University of Valencia our group discovered changes in cell-to-cell communication in ME/CFS and assessed diagnostic value of microRNAs from plasma exosomes in ME/CFS. These studies contributed to better understanding of the dysregulation of immune function in GWI and ME/CFS.

  1. Almenar-Pérez E., Sarría L., Nathanson L., Oltra E. Assessing diagnostic value of microRNAs from peripheral blood mononuclear cells and extracellular vesicles in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome. Scientific reports. 2020, 10(1), 2064. doi.org/10.1038/s41598-020-58506-5
  2. González-Cebrián A., Almenar-Pérez E., Xu J., Yu T., Huang W. E., Giménez-Orenga K., Hutchinson S., Lodge T., Nathanson L., Morten K. J., Ferrer A., Oltra E. Diagnosis of myalgic encephalomyelitis/chronic fatigue syndrome with partial least squares discriminant analysis: relevance of blood extracellular vesicles. Frontiers in Medicine. 2022, 9, 842991. doi:10.3389/fmed.2022.842991
  3. Van Booven D, Zarnowski O, Perez M, Sarria L, Collado F, Hansotia K, Riegle S, Finger T, Fletcher MA, Klimas NG, Nathanson L. The effect of stress on the transcriptomes of circulating immune cells in patients with Gulf War Illness. Life Sci. 2021 Sep 15;281:119719. doi: 10.1016/j.lfs.2021.119719. Epub 2021 Jun 16. PMID: 34144055.
  4. Cheema AK, Sarria L., Bekheit M., Collado F., Almenar-Pérez E., Martín-Martínez E., Alegre J., Castro-Marrero J., Fletcher MA, Klimas NG, Oltra E, Nathanson L. Unravelling myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS): Gender-specific changes in the microRNA expression profiling in ME/CFS. Journal of cellular and molecular medicine. 2020, 24(10), 5865–5877. https://doi.org/10.1111/jcmm.15260
  5. Trivedi MS, Abreu MM, Sarria L, Rose N, Ahmed N, Beljanski V, Fletcher MA, Klimas NG, Nathanson L. Alterations in DNA Methylation Status Associated with Gulf War Illness. DNA Cell Biol. 2019 Jun;38(6):561-571. PubMed PMID: 30920300
Complete List of Published Work

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