Barry and Judy Silverman College of Pharmacy—Ph.D. Program 219 Ph.D. Course Descriptions Note: Listed at the end of each entry are lecture hours, laboratory hours, and credit hours. PHRP 7001—Health Economics This course will introduce students to the economic analysis of health care markets and the production of health. This course covers a variety of topics, including the determinants of health; the supply of, and demand for, health care services; the impact of insurance on the demand for health care services; the role of government in health care markets; the market for pharmaceuticals; and the economic evaluation of health care programs. This course focuses on the application of economic analysis as it relates to provision of health care and emerging health care trends in the United States and throughout the world. It also focuses on understanding how health care markets differ from other markets, specifically on the economics of the health care sector and its major players (e.g., the government, insurers, providers, and patients). Economic concepts and tools will be used to analyze the healthcare system and to examine implications and issues in health policy. (48-0-3) PHRP 7004—Advanced Physical Pharmacy This course presents application of underlying physical principles to formulate and develop various pharmaceutical products. It describes physical principles in both solid and nonsolid states. Students will learn how basic physical principles are applied in development of current and novel pharmaceutical solids, semi-solids, and homogeneous and heterogeneous systems. Moreover, the course describes the importance, properties, and application of different polymer systems, new drug carriers, and rheology modifiers in developing current and novel dosage forms. Drug stability and solubility and approaches to enhance the solubility of poorly soluble drugs will also be discussed. (48-0-3) PHRP 7006—Advanced Pharmacology This course will apply the principles of organic chemistry, biochemistry, physiology, and pathophysiology to understand drug actions at the receptor, cellular, and systems levels under physiological and pathological conditions. Special emphasis will be placed on students’ understanding of determinants of drug absorption, distribution, physiological receptors, drugreceptor interaction, drug metabolism, and elimination. This course will also focus on the drugs that act on the autonomic nervous system, cardiovascular system, and blood components as well. The rationale for the use of these therapeutic agents; their effects on cells, tissues, organ systems, and patients; the mechanisms underlying these effects; the therapeutic value of specific drug effects; and the adverse effects of the drugs will be addressed as well. (64-0-4) PHRP 7012—Clinical Drug Development: Advanced Pharmacokinetics and Biopharmaceutics This course deals with the principles that explain the processes of absorption, distribution, and elimination of drugs. The advances in pharmacokinetic modeling, compartmental analysis, model-independent methods, single and multiple dosing, protein binding, metabolite kinetics, interspecies scaling to translate animal data to humans, effect of disease states, and data analysis using relevant software will be discussed, applying the principles of biopharmaceutics and pharmacokinetics to the design of controlled release and targeted drug delivery systems. Emphasis is on bioequivalence and bioavailability of traditional pharmaceutical dosage forms and novel drug delivery systems, including the assessment of biosimilars. (48-0-3) PHRP 7020—Experimental Statistics and Informatics This course provides an overview of the principles of experimental statistics and informatics that are relevant to the experimental design of studies, as well as interpretation and processing of the information garnered from these studies, in the biomedical sciences, but particularly in the area of molecular medicine and pharmacogenomics. (16-0-1) PHRP 7021—Population Health and Public Policy This highly interactive course introduces students to: (1) the fundamental concepts and frameworks used for the study of population health and public policy; (2) the financing and managing of health systems at the local and international levels; and (3) the formulation and analysis of public health policies. The course will emphasize the intersection of public health and the determinant of drug use and pharmacy-related policies. Students will analyze and critically evaluate existing health policies, public health actions, and reforms. Students are expected to contribute and participate in the discussion of current research, case studies, and policies. Student learning will be assessed through oral exams, written assignments, presentations, and an analytical paper. This course will provide skills for the conceptualization of research projects addressing current health issues related to pharmacy. (48-0-3) PHRP 7023—Pharmaceutical Marketing This course is intended to provide the graduate student with an in-depth understanding of the global development and marketing of pharmaceuticals with an emphasis on the U.S. system. (48-0-3)
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