Faculty & Staff Profiles

Stephen James O'Brien, Ph. D.
Professor
Stephen James O'Brien sobrien1@nova.edu 
lgdchief@gmail.com

Stephen J. O’Brien served as Chief of the Laboratory of Genomic Diversity at the National Cancer Institute (NCI), National Institutes of Health (NIH) from 1986-2011. In December 2011, he joined the Theodosius Dobzhansky Center for Genome Bioinformatics, St. Petersburg State University as Chief Scientific Officer. In 2012 he also joined the NSU Oceanographic Center as Professor.  He also serves as advisor to the NSU Office of Research and Technology Transfer.

His research interests and expertise span human and comparative genomics, genetic epidemiology, HIV/AIDS, retro-virology, bioinformatics biodiversity and species conservation. Dr. O’Brien served as Editor of six editions of Genetic Maps: Locus Maps of Complex Genomes (1980-1993) (Cold Spring Harbor Laboratory Publications); Editor of Journal of Heredity (American Genetics Association) from 1987-2007; Editor of “Atlas of Mammalian Chromosomes” (John Wiley Inc. NYC, 2006) and author of “Tears of the Cheetah And Other Tales From The Genetic Frontier” (St. Martin’s Press NYC, 2004).

Dr. O’Brien received his B.S. in Biology in 1966 from St. Francis College, which presented him with a Distinguished Alumni Award in 1994. In 1971 he earned a Ph.D. in Genetics from Cornell University which honored him as “Andrew Dixon White Endowed Professor at Large” in 1998. Dr. O’Brien has a strong dedication to education, evidenced by his appointments as adjunct professor at twelve universities. He has mentored more than fifteen Ph.D. students and multiple postdoctoral fellows. Since 1996 he has directed an internationally heralded short course sponsored by Smithsonian and American Genetics Association, entitled “Recent Advances in Conservation Genetics”, the most recent (2012) edition at The Smithsonian Tropical Research Institute , Panama. He chaired the most recent G10K conference (http://genome10k.soe.ucsc.edu/) in Hollywood, Florida.

Books

Tears of the Cheetah: And Other Tales from the Genetic Frontier [Hardcover]
Dr. Stephen J. O’Brien

Atlas of Mammalian Chromosomes [Hardcover]
Stephen J. O’Brien (Editor),
Joan C. Menninger (Editor),
William G. Nash

Genetic Maps: Locus Maps of Complex Genomes (Genetic Maps) [Hardcover]
Stephen J. O’Brien 

Edited Volumes
  1. O’Brien, S.J., Menninger, J. C and Nash, W. G.: An Atlas of Mammalian Genomes.  John Wiley & Sons Publishers, New York, NY, 2006.
  2. O’Brien, S.J. (Ed.):  Isozyme Bulletin, 1976, Vol. 9, pp. 1‑79.
  3. O’Brien, S.J. (Ed.):  Isozyme Bulletin, 1977, Vol. 10, pp. 1‑90.
  4. O’Brien, S.J. (Ed.):  Isozyme Bulletin, 1978, Vol. 11, pp. 1‑68.
  5. O’Brien, S.J. (Ed.):  Genetic Maps, 1980, Vol. 1, pp. 1‑28
  6. O’Brien, S.J. (Ed.):  Genetic Maps, 1982, Vol. 2, pp. 1‑406.
  7. O’Brien, S.J. (Ed.):  Genetic Maps, 1984.  Cold Spring Harbor Laboratory Press, New York, Vol. 3, 1984, 584 pp.
  8. O’Brien, S.J. (Ed.):  Genetic Maps, 1987.  Cold Spring Harbor Laboratory Press, New York, Vol. 4, 842 pp.
  9. Clegg, M. T., and O’Brien, S.J. (Eds.):  Molecular Evolution, 1990, Vol. 122, Proceedings of a UCLA Colloquium, UCLA Symposia on Molecular and Cellular Biology, Lake Tahoe, CA, Wiley-Liss, New York, N.Y., pp. 1-322.
  10. O’Brien, S.J. (Ed.):  Genetic Maps:  Locus Maps of Complex Genomes.  Fifth Edition.  1990.  Cold Spring Harbor Laboratory Press, New York, Unabridged 1104 pp.
  11. O’Brien, S.J. (Ed.):  Genetic Maps:  Locus Maps of Complex Genomes.  Fifth Edition.  1990.  Cold Spring Harbor Laboratory Press, New York.  Published in six volumes:
    Book 1 Viruses 186 pp
    Book 2 Bacteria, Protozoa, and Algae 138 pp
    Book 3 Lower Eukaryotes 206 pp
    Book 4 Nonhuman Vertebrates 180 pp
    Book 5 Human Maps 262 pp
    Book 6 Plant  152 pp
  12. O’Brien, S.J. (Ed.):  Genetic Maps:  Locus Maps of Complex Genomes.  Sixth Edition.  1993.  Cold Spring Harbor Laboratory Press, New York.  Unabridged 1617 pp.
  13. O’Brien, S.J. (Ed.):  Genetic Maps:  Locus Maps of Complex Genomes.  Sixth Edition.  1993.  Cold Harbor Laboratory Press, New York.  Published in six volumes:
    Book 1  Viruses 205 pp
    Book 2 Bacteria, Protozoa, and Algae 181 pp
    Book 3 Lower Eukaryotes 318 pp
    Book 4 Nonhuman Vertebrates 342 pp
    Book 5 Human Maps 310 pp
    Book 6 Plants 261 pp
  14. O’Brien, S.J. and Clegg, M. T. (Eds.):  Genes and Genomes.  Curr. Opin. Genet. Devel. 3:  835-998, 1993.
  15. Hartl, D. L., Kafatos, F., and O’Brien, S.J. (Eds.):  Genomes and Evolution.  Curr. Opin. Genet. Devel. 5:  705-847, 1995.
  16. O’Brien, S.J. and Fraser, C. M.  Genomes and Evolution.  Curr. Opin. Genet. Devel. 15: 569-665, 2005
Scientific Articles
  1. O’Brien, S.J. and MacIntyre, R. J.: An analysis of gene enzyme variability in natural populations of Drosophila melanogaster and D. simulans. Am. Nat. 103: 97 113, 1969.
  2. O’Brien, S.J. and MacIntyre, R. J.: Empirical demonstration of a transient linkage disequilibrium in Drosophila. Nature 230: 335 336, 1971.
  3. O’Brien, S.J. and MacIntyre, R. J.: A biochemical genetic map of the Drosophila genome. Drosophila Info. Serv. 46: 89 93, 1971.
  4. O’Brien, S.J. and MacIntyre, R. J.: α glycerophosphate cycle in Drosophila melanogaster. I. Biochemical and developmental aspects. Biochem. Genet. 7: 141-161, 1972.
  5. O’Brien, S.J. and MacIntyre, R. J.: The α glycerophosphate cycle in D. melanogaster. II. Genetic aspects. Genetics 71: 127 138, 1972.
  6. O’Brien, S.J. and MacIntyre, R. J.: The α glycerophosphate cycle in D. melanogaster. III. The effect of “null” mutations at α Gphd 1 locus on viability. Am. Nat. 106: 967 971, 1972.
  7. O’Brien, S.J.: On estimating functional gene number in eukaryotes. Nature New Biol. 242: 52 54, 1973.
  8. O’Brien, S.J.: Comparative analysis of malate dehydrogenase of Drosophila melanogaster. Biochem. Genet. 10: 191 205, 1973.
  9. O’Brien, S.J. and Gethmann, R. C.: Segmental aneuploidy as a probe for structural genes in Drosophila: Mitochondrial membrane enzymes. Genetics 75: 155 167, 1973.
  10. O’Brien, S.J. and Shimada, Y.: The α glycerophosphate cycle in Drosophila melanogaster. IV. Metabolic, ultrastructural, and adaptive consequences of α Gphd 1 “null” mutations. J. Cell Biol. 63: 864 882, 1974.
  11. O’Brien, S.J., Boone, C. W., Simonson, J. M., and Austin, F.: The paired label assay for cell surface antigens. Tissue Cult. Assoc. Manual 2: 423 427, 1975.
  12. O’Brien, S.J.: Biochemical mutants of Drosophila melanogaster. In: King, R. C. (Ed.) Handbook of Genetics, Vol. III. New York, Plenum, 1975, pp. 669 678.
  13. O’Brien, S.J., Kleiner, G., Kern, J., and Reynolds, J.: Zymogram phenotypes of widely used cell lines from various animal species. Isozyme Bull. 9: 20 27, 1976.
  14. O’Brien, S.J.: Bvr 1, a restriction locus of a type C RNA virus in the feline cellular genome: Identification, location, and phenotypic characterization in cat x mouse somatic cell hybrids. Proc. Natl. Acad. Sci. USA 73: 4618-4622, 1976.
  15. O’Brien, S.J., Simonson, J. M., and Boone, C. W.: Expression of virus structural proteins on murine cell surfaces in association with the production of murine leukaemia virus. J. Gen. Virol. 33: 355 360, 1976.
  16. O’Brien, S.J.: Isozymes and allozymes as genetic footprints of cultured cells. In Petricianni, J. (Ed.): Proceedings of the FDA Conference on Cell Substrates for Vaccine Production, 1976, pp. 46n 59n.
  17. MacIntyre, R. J. and O’Brien, S.J.: Interacting gene enzyme systems in Drosophila. Ann. Rev. Genet. 10: 281 318, 1976.
  18. O’Brien, S.J., Kleiner, G., Olson, R., and Shannon, J.: Enzyme polymorphisms as genetic signatures in human cell cultures. Science 195: 1345 1348, 1977.
  19. O’Brien, S.J. and Boone, C. W.: Expression of feline leukemia virus antigens on cat lymphoma cells: Kinetics of biosynthesis. J. Gen. Virol. 35: 511 523, 1977.
  20. Lemons, R. S., O’Brien, S.J., and Sherr, C.J.: A new genetic locus, Bevi, on human chromosome 6 which controls the replication of baboon type C virus in human cells. Cell 12:251-262, 1977.
  21. O’Brien, S.J. and MacIntyre, R. J.: Genetics and biochemistry of enzymes and specific proteins of Drosophila. In Wright, T. R. F. and Ashburner, M. (Eds.): Genetics and Biology of Drosophila, Vol IIa. New York, Academic, 1977, pp. 395 551.
  22. O’Brien, S.J., Simonson, J. M., and Davis, S.: Deposition of retrovirus associated antigens (p30 and gp70) on cell membranes of feline and murine leukemia virus infected cells. J. Gen. Virol. 38: 483 496, 1978.
  23. O’Brien, S.J. and Simonson, J. M.: Bvr 1: A restriction locus of a type C RNA virus in the feline cellular genome: Pleiotropic restriction of endogenous BALB virus in cat X mouse somatic cell hybrids. J. Exp. Med. 147: 219-232, 1978.
  24. Lemons, R. S., O’Brien, S.J., and Sherr, C. J.: The Bevi locus (chromosome 6) encodes a post-penetrational cellular function required for baboon endogenous virus replication in human cells. Cytogenet. Cell Genet. 22: 255-259, 1978.
  25. Lemons, R. S., Nash, W. G., O’Brien, S.J., Benveniste, R. E., and Sherr, C. J.: A gene (Bevi) on human chromosome 6 is an integration site for baboon type C DNA provirus in human cells. Cell 14: 995-1005, 1978.
  26. Engel, L. W., Young, N. A., Tralka, T. S., Lippman, M. E., O’Brien, S.J., and Joyce, M. J.: Establishment and characterization of three new continuous cell lines derived from human breast carcinomas. Cancer Res. 38:3352-3364, 1978.
  27. Kucera, L. S., Simonson, J. M., O’Brien, S.J., and Coon, H.: On the Lucke tumor origin of LT 1 cells. J. Natl. Cancer Inst. 60: 493-495, 1978.
  28. O’Brien, S.J. and Rice, M. C.: Genetic aspects of carcinogenesis and carcinogen testing in outbred Swiss mice. J. Toxicol. Environ. Health 5:69-81, 1979.
  29. Noguchi, P., Wallace, R., Johnson, J., Earley, E. M., O’Brien, S.J., Ferrone, S., Pellegrino, M. A., Milstein, J., Needy, C., Browne, W., and Petriceianni, J.: Characterization of the WIDR: A human colon carcinoma cell line. In Vitro 15: 401-408, 1979.
  30. Surti, U., Szulman, A. E., and O’Brien, S.J.: Complete (classic) hydatidiform mole with 46,XY karyotype of paternal origin. Hum. Genet. 51: 153-155, 1979.
  31. O’Brien, S.J. and Rice, M. C.: Specific genetic loci as targets of carcinogens and tumor promoters in mammals. J. Environ. Pathol. Toxicol. 2: 1055-1068, 1979.
  32. Gail, M. H., Weiss, G. H., Mante, N., and O’Brien, S.J.: A solution to the generalized birthday problem with application to allozyme screenings for cell culture contamination. J. Appl. Prob. 16:242-251, 1979.
  33. Gardner, M. B., Rasheed, S., Pal, B. K., Estes, J. D., and O’Brien, S.J.: Akvr 1, a dominant MuLV restriction gene segregates in leukemia prone wild mice. In Yohn, D. S., Lapin, B. A., and Blakeslee, J. R. (Eds.): Comparative Leukemia Research. New York, Elsevier/North Holland, 1979, pp. 149-150.
  34. Pearson, P. L., Roderick, T. H., Davisson, M. T., Garver, J. J., Warburton, D., Lalley, P. A., and O’Brien, S.J.: Report of the committee on comparative gene mapping. Cytogenet. Cell Genet. 25: 82-95, 1979.
  35. Rice, M. C. and O’Brien, S.J.: Genetic variance of laboratory outbred Swiss mice. Nature 283: 157-161, 1980.
  36. Gardner, M. B., Rasheed, S., Pal, B. K., Estes, J. D., and O’Brien, S.J.: Akvr 1, a dominant murine leukemia virus restriction gene is polymorphic in leukemia prone wild mice. Proc. Natl. Acad. Sci. USA 77:531-535, 1980.
  37. O’Brien, S.J., Shannon, J. E., and Gail, M. H.: A molecular approach to the identification and individualization of human and animal cells in culture: Isozyme and allozyme genetic signatures. In Vitro 16: 119 135, 1980.
  38. Rice, M. C., Gardner, M. B., and O’Brien, S.J.: Genetic diversity in leukemia-prone feral house mice infected with murine leukemia virus. Biochem. Genet. 8: 915 928, 1980.
  39. Nelson Rees, W. A., Hunter, L., Darlington, G. J., and O’Brien, S.J.: Characteristics of HeLa strains: Permanent vs. variable features. Cytogenet. Cell Genet. 27: 216 231, 1980.
  40. O’Brien, S.J.: The extent and character of biochemical genetic variation in the domestic cat (Felis catus). J. Hered. 71: 2 8, 1980.
  41. O’Brien, S.J., Gail, M. H., and Levin, D. L.: Correlative genetic variation in natural populations of cats, mice and men. Nature 288: 580 583, 1980.
  42. Gardner, M. B., Rasheed, S., Pal, B. K., Estes, J. D., Berman, E., and O’Brien, S.J.: Genetic analysis of Akvr 1 relative to other murine retrovirus restriction loci. In Baltimore, D., Huang, A. S., and Fox, C. F. (Eds.): Proceedings of ICN UCLA Symposium on Animal Virology. 1980, pp. 223 232.
  43. O’Brien, S.J., Nash, W. G., Simonson, J. M., and Berman, E. J.: Establishment of a biochemical genetic map of the domestic cat (Felis catus). In Hardy, W. D., Essex, M., and McClelland, A. J. (Eds.): Feline Leukemia Virus. New York, Elsevier/North Holland, 1980, pp. 401 412.
  44. O’Brien, S.J. and Nash, W. G.: Somatic cell genetic analysis of enzyme structural genes of the domestic cat (Felis catus). Carnivore Genet. 4: 81 88, 1980.
  45. Harris, N. L., Gang, D. L., Quay, S. C., Poppema, S., Nelson Rees, W. A., and O’Brien, S.J.: Contamination of Hodgkin’s disease cell cultures. Nature 289: 228-230, 1981.
  46. O’Brien, S.J., Simonson, J. M., Grabowski, M. W., and Barile, M. F.: Analysis of multiple isoenzyme expression among twenty two species of Mycoplasma and Acholeplasma. J. Bacteriol. 146: 222 232, 1981.
  47. O’Brien, S.J., Nash, W. G., Benveniste, R. E., Wildt, D. E., and Bush, M. E.: Palaeontological and molecular views of panda phylogeny. Nature 319: 428, 1986.
  48. O’Brien, S.J. and Nash, W. G.: Genetic mapping in mammals: Chromosome map of the domestic cat. Science 216: 257 265, 1982.
  49. O’Brien, S.J.: Plausible alternatives to bottlenecks to explain reduced genetic diversity. Trends Ecol. Evol. 4: 176-178, 1989.
  50. Anagnou, N. P., Antonarakis, S. E., O’Brien, S.J., and Nienhuis, A. W.: A novel form of human polymorphism involving the hDHFR-psi 1 pseudogene identifies three RFLPs. Nucleic Acids Res. 15: 5501, 1987.
  51. O’Brien, S.J., Moore, J. L., Martin, M. A., and Womack, J. E.: Evidence for the horizontal acquisition of murine AKR virogenes by recent horizontal infection of the germ line. J. Exp. Med. 155: 1120 1123, 1982.
  52. O’Brien, S.J. and Barile, M. F.: Isozyme resolution in mycoplasmas. In Razin, S. and Tully, J. G. (Eds.): Methods of Mycoplasmology, Vol. I. New York, Academic, 1982, pp. 391 396.
  53. O’Brien, S.J., Nash, W. G., Winkler, C. A., and Reeves, R. H.: Genetic analysis in the domestic cat as an animal model for inborn errors, cancer and evolution. Prog. Clin. Biol. Res. 94: 67-90, 1982.
  54. O’Brien, S.J., Simonson, J. M., and Eichelberger, M. A.: Genetic analysis of hybrid cells using isozyme markers as monitors of chromosome segregation. In Shay, J. W. (Ed.): Techniques in Somatic Cell Genetics. New York, Plenum, 1982, pp. 513 524.
  55. Pearson, P. L., Roderick, T. H., Davisson, M. T., Lalley, P. A., and O’Brien, S.J.: Report of the committee on comparative mapping. Oslo Conference (1981): Sixth International Workshop on Human Gene Mapping. Cytogenet. Cell Genet. 32: 208 220, 1982.
  56. Nash, W. G. and O’Brien, S.J.: Conserved regions of homologous G banded chromosomes between orders in mammalian evolution: Carnivores and primates. Proc. Natl. Acad. Sci. USA 79: 6631 6635, 1982.
  57. O’Brien, S.J. and Johnson, P. A.: An abridged human gene map including oncogenes, neoplasia-related loci and biochemical loci whose homologous counterparts have been assigned in other mammalian species. In O’Brien, S.J. (Ed.): Genetic Maps, Vol. 4. New York, Cold Spring Harbor Laboratory, 1987, pp. 598-604.
  58. O’Brien, S.J.: Genetic map of the domestic cat, Felis catus. In O’Brien, S.J. (Ed.): Genetic Maps, Vol. 4. New York, Cold Spring Harbor Laboratory, 1987, pp. 482-485.
  59. O’Brien, S.J., Nash, W. G., Winkler, C. A., Simonson, J. M., and Lemons, R. S.: Control of integration of baboon endogenous virus in human chromosomes by the BEVI locus. In Yohn, D. S. and Blakeslee, R. J. (Eds.): Comparative Leukemia Research. New York, Elsevier/North Holland, 1981, pp. 399 400.
  60. O’Brien, S.J., Wildt, D. E., Simonson, J. M., Brand, D. J., Ebedes, H., van Dyk, A., Meltzer, D., Simmons, L. G., and Bush, M.: On the extent of genetic variation of the African cheetah, Acinonyx jubatus. In Fowler, M. (Ed.): Proceedings of the American Association of Zoo Veterinarians, 1981, pp. 74 77.
  61. Seibert, K., Shafie, S. M., Tricke, T. J., Whang Peng, J. J., O’Brien, S.J., Toney, J. H., Huff, K. K., and Lippman, M. E.: Clonal variation of MCF 7 breast cancer cells in vivo and in athymic nude mice. Cancer Res. 43: 2223 2239, 1983.
  62. Surti, U., Szulman, A. E., and O’Brien, S.J.: Dispermic origin and clinical outcome of three complete hydatidiform moles with 46,XY karyotype. J. Obstet. Gynecol. 144: 84 87, 1982.
  63. O’Brien, S.J., Wildt, D. E., Goldman, D., Merril, C. R., and Bush, M.: The cheetah is depauperate in genetic variation. Science 221: 459 462, 1983.
  64. Wildt, D. E., Bush, M., Howard, J. G., O’Brien, S.J., Meltzer, D., van Dyk, A., Ebedes, H., and Brand, D. J.: Unique seminal quality in the South African cheetah and a comparative evaluation in the domestic cat. Biol. Reprod. 29:1019 1025, 1983.
  65. O’Brien, S.J., Simonson, J. M., Razine, S., and Barile, M. F.: On the distribution and characteristics of isozyme expression in Mycoplasma, Acholeplasma, and Ureaplasma species. Yale J. Biol. Med. 56: 701 708, 1983.
  66. O’Brien, S.J., Bonner, T. I., Cohen, M., O’Connell, C., and Nash, W. G.: Mapping of an endogenous retroviral sequence to human chromosome 18. Nature 303: 74 77, 1983.
  67. O’Brien, S.J., Nash, W. G., Goodwin, J. L., Lowy, D. R., and Chang, E. H.: Dispersion of the ras family of transforming genes to four different chromosomes in man. Nature 302:839-842, 1983.
  68. O’Brien, S.J., Berman, E. J., Estes, J. D., and Gardner, M. B.: Murine retroviral restriction genes Fv 4 and Akvr 1 are alleles of a single locus. J. Virol. 47: 649 651, 1983.
  69. Barile, M. F., Grabowski, M. W., Stephens, E. B., O’Brien, S.J., Simonson, J. M., Izumikawa, K., Chandler, D. K. F., Taylor Robinson, D., and Tully, J. G.: Mycoplasma hominis tissue cell interactions: A review with new observations on phenotypic and genotypic properties. Sex Transm Dis 10: 345 354, 1983.
  70. Reeves, R. H. and O’Brien, S.J.: Molecular genetic characterization of the RD 114 gene family of endogenous feline retroviral sequences. J Virol 52:164-171, 1984.
  71. Reeves, R. H., Nash, W. G., and O’Brien, S.J.: Genetic mapping of endogenous RD 114 retroviral sequences of domestic cats. J Virol 56:303-306, 1985.
  72. Bonner, T., O’Brien, S.J., Nash, W. G., Rapp, U. R., Morton, C. C., and Leder, P.: The human homologs of the raf (mil) oncogene are located on human chromosomes 3 and 4. Science 223:71-74, 1984.
  73. Wayne, R. and O’Brien, S.J.: Empirical demonstration that structural gene and morphometric variation of mandible traits are uncoupled between mouse strains. J. Mammal. 67:441-449, 1986.
  74. Seigel, L. J., Harper, M. E., Wong Staal, F., Gallo, R. C., Nash, W. G., and O’Brien, S.J.: Gene for T cell growth factor: Location on human chromosome 4q and feline chromosome B1. Science 223: 175 178, 1984.
  75. Roderick, T. H., Lalley, P. A., Davisson, M. T., O’Brien, S.J., Womack, J. E., Creau Goldberg, N., Echard, G., and Moore, K. L.: Report of the committee on comparative mapping. Cytogenet. Cell Genet. 37: 312 339, 1984.
  76. O’Brien, S.J., Reeves, R. H., Simonson, J. M., Eichelberger, M. A., and Nash, W. G.: Parallels of genomic organization and endogenous retrovirus organization in cat and man. Develop. Genet. 4: 341 354, 1984.
  77. O’Brien, S.J., Nash, W. G., Bauer, R., Chang, E. H., and Seigel, L. J.: Trends in chromosomal and oncogene evolution in vertebrates. In Patterson, M. K. (Ed.): Uses and Standardization of Vertebrate Cell Cultures. In Vitro Monograph No. 5. Gaithersburg, Tissue Culture Association, 1984, pp. 204 214.
  78. Seigel, L. J., Nash, W. G., Manzari, V., Wong Staal, F., Gallo, R. C., and O’Brien, S.J.: A genetic analysis of human T-cell leukemia virus integration in HUT 102 and the localization of the structural gene for T cell growth factor to chromosome 4. In Gallo, R. C. and Essex, M. (Eds): Human T-Cell Leukemia/Lymphoma Viruses. New York, Cold Spring Harbor Laboratory, 1984, pp. 167 180.
  79. O’Brien, S.J., Goldman, D., Knight, J., Moore, H. D., Wildt, D. E., Bush, M., Montali, R. J., and Kleiman, D.: Giant panda paternity. Science 223: 1127 1129, 1984.
  80. Anagnou, N. P., O’Brien, S.J., Shimada, T., Nash, W. G., Chen, M., and Nienhius, A. W.: Chromosomal organization of the human dihydrofolate reductase genes: Dispersion, selective amplification and a novel form of polymorphism. Proc. Natl. Acad. Sci. USA 81: 5170 5174, 1984.
  81. O’Brien, S.J., Roelke, M. E., Marker, L., Newman, A., Winkler, C. A., Meltzer, D., Colly, L., Evermann, J. F., Bush, M., and Wildt, D. E.: Genetic basis for species vulnerability in the cheetah. Science 227: 1428 1434, 1985.
  82. Newman, A., Bush, M., Wildt, D. E., van Dam, D., Frankehuis, M., Simmons, L., Phillips, L., and O’Brien, S.J.: Biochemical genetic variation in eight endangered feline species. J. Mammal. 66: 256 267, 1985.
  83. Stephens, J. C., Chipperfield, M. A., and O’Brien, S.J.: An abridged human gene map. In O’Brien, S.J. (Ed.): Genetic Maps: Locus Maps of Complex Genomes, Sixth Edition. New York, Cold Spring Harbor Laboratory, 1993, pp. 5.209-5.239
  84. O’Brien, S.J., Seuanez, H. N., and Womack, J. E.: On the evolution of genome organization in mammals. In: MacIntyre, R. J. (Ed.) Molecular Evolutionary Genetics (Monographs in Evolutionary Biology Series). New York, Plenum, 1985, pp. 519 589.
  85. Burk, R. D., Szabo, P., O’Brien, S.J., Nash, W. G., Yu, L., and Smith, K. D.: Organization and chromosomal specificity of autosomal homologs of human Y chromosome repeated DNA. Chromosoma 92: 225 233, 1985.
  86. O’Connell, C., O’Brien, S.J., Nash, W. G., and Cohen, M.: ERV3, a full length human endogenous provirus: Chromosomal localization and evolutionary relationship. J. Virol. 138: 225 234, 1984.
  87. Wayne, R. K., Modi, W. S., and O’Brien, S.J.: Morphological variability in the cheetah (Acinonyx jubatus), a genetically uniform species. Evolution 40: 78 85, 1986.
  88. Collier, G. E. and O’Brien, S.J.: A molecular phylogeny of the Felidae: Immunological distance. Evolution 39: 473 487, 1985.
  89. Longo, D. L., Gelmann, E. P., Cossman, J., Young, R. A., Gallo, R. C., O’Brien, S.J., and Matis, L. A.: Isolation of HTLV transformed B lymphocyte clone from a patient with HTLV associated adult T cell leukaemia. Nature 310: 505 506, 1984.
  90. O’Brien, S.J.: Genetic and reproductive approaches to an endangered species, the giant panda. In Wagner, R. O. (Ed.): Proceedings of the Association of Zoological Parks and Aquariums. Miami, AAZPA, 1984, pp. 169 180.
  91. O’Brien, S.J., Benveniste, R. E., Nash, W. G., Simonson, J. M., Eichelberger, M. A., Wildt, D. E., and Bush, M.: Constructing a molecular phylogeny of the giant panda, Ailuropoda melanoleuca. In Klos, H. G. and Fradrich, H. (Eds.): Proceedings International Symposium on Giant Panda, 1984, Vol. 10. Berlin, Bongo, 1985, pp. 175-182.
  92. O’Brien, S.J., Nash, W. G., Wildt, D. E., Bush, M. E., and Benveniste, R. E.: A molecular solution to the riddle of the giant panda’s phylogeny. Nature 317: 140-144, 1985.
  93. Brownell, E., O’Brien, S.J., Nash, W. G., and Rice, N.: Genetic characterization of human c rel sequences. Mol. Cell. Biol. 5: 2826-2831, 1985.
  94. Goldman, D., Goldin, L. G., Rathnagiri, P., O’Brien, S.J., Egeland, J. A., and Merril, C. R.: Twenty seven protein polymorphisms by two dimensional electrophoresis of serum erythrocytes and fibroblasts in two pedigrees. Am. J. Hum. Genet. 37: 898-911, 1985.
  95. Surti, U., Szulman, A. E., Wagner, K., Leppert, M., White, R., and O’Brien, S.J.: Tetraploid partial hyatidiform moles: Two cases with a triple paternal contribution and a 92,XXXY karyotype. Hum. Genet. 72: 15-21, 1986.
  96. Wayne, R. K., Forman, L., Newman, A. K., Simonson, J. M., and O’Brien, S.J.: Genetic monitors of captive zoological populations: Morphological and electrophoretic assays. Zoo Biol. 5: 215-232, 1986.
  97. Goldman, D., Giri, P.R., and O’Brien, S.J.: A molecular phylogeny of the hominoid primates as indicated by two-dimensional protein electrophoresis. Proc. Natl. Acad. Sci. USA 84: 3307-3311, 1987.
  98. Forman, L., Kleiman, D. G., Bush, M. R., Dietz, J. M., Ballou, J. D., Phillips, L. G., Dietz, J. L., Coimbra Filho, A. F., and O’Brien, S.J.: Genetic variation within and among lion tamarins. Am. J. Phys. Anthropol. 71: 1-11, 1986.
  99. Nienhuis, A. W., Bunn, H. F., Turner, P. H., Gopal, T. V., Nash, W. G., O’Brien, S.J., and Sherr, C. J.: Expression of the human c fms proto oncogene in hematopoietic cells and its deletion in the 5q- syndrome. Cell 42: 421 428, 1985.
  100. Watson, D. K., Smith, M. J., Kozak, C., Reeves, R., Gearhart, J., Nunn, M. F., Nash, W., Fowle, J. R., III, Duesberg, P., Papas, T. S., and O’Brien, S.J.: Conserved chromosomal positions of dual domains of the ets proto oncogene in cats, mice and man. Proc. Natl. Acad. Sci. USA 83: 1792 1796, 1986.
  101. Watson, D. K., McWilliams Smith, M. J., Nunn, M. F., Duesberg, P. H., O’Brien, S.J., and Papas, T. S.: The ets sequence from the transforming gene of avian erythroblastosis virus, E26, has unique domains on human chromosomes 11 and 21: Both loci are transcriptionally active. Proc. Natl. Acad. Sci. USA 82: 7294 7298, 1985.
  102. Brownell, E., Kozak, C. A., Fowle, J. R. 3rd, Modi, W. S., Rice, N. R., and O’Brien, S.J.: Comparative genetic mapping of cellular rel sequences in man, mouse, and the domestic cat. Am. J. Hum. Genet. 39: 194-202, 1986.
  103. Berman, E. J., Nash, W. G., Seuanez, H. N., and O’Brien, S.J.: Chromosomal mapping of enzyme loci in the domestic cat: GSR to C2, ADA and ITPA to A3, and LDHA ACP2 to D1. Cytogenet Cell Genet 41: 114-120, 1986.
  104. Seigel, L. J., Nash, W. G., Poiesz, B. J., Moore, J. L., and O’Brien, S.J.: Dynamic and nonspecific dispersal of human T-cell leukemia/lymphoma virus type I integration in cultured lymphoma cells. Virology 154: 67-75, 1986.
  105. Seigel, L. J., Ratner, L., Josephs, S. F., Derse, D., Feinberg, M. B., Reyes, G. R., O’Brien, S.J., and Wong Staal, F.: Transactivation induced by human T lymphotropic virus type III (HTLV III) maps to a viral sequence encoding 58 amino acids and lacks tissue specificity. Virology 148: 226-231, 1986.
  106. Steele, P. E., Martin, M. A., Rabson, A. B., Bryan, T., and O’Brien, S.J.: Amplification and chromosomal dispersion of human endogenous retroviral sequences. J Virol 59: 545-550, 1986.
  107. O’Brien, S.J.: Genetic analysis in mammals: Past, present, and future. Basic Life Sci. 37: 139-149, 1986.
  108. O’Brien, S.J., Wildt, D. E., and Bush, M.: The cheetah in genetic peril. Sci. Am. 254: 84-92, 1986.
  109. Papas, T. S., Watson, D. K., Sacchi, N., O’Brien, S.J., and Ascione, R.: The mammalian ets genes: Two unique chromosomal locations in cat, mice and man and novel translocated position in human leukemias. In Hagenbeck, A. and Lowenberg, B. (Eds.): Minimal Residual Disease in Acute Leukemia: 1986. Boston, Martinus Nijhoff/Dodrecht, 1986, pp. 23-42.
  110. Wildt, D. E., Schiewe, M. C., Schmidt, P. M., Goodrowe, K. L., Howard, J. G., Phillips, L. G., O’Brien, S.J., and Bush, M.: Developing animal model systems for embryo technologies in rare and endangered wildlife. Theriogenology 25: 33 51, 1986.
  111. O’Brien, S.J., Haskins, M. E., Winkler, C. A., Nash, W. G., and Patterson, D. F.: Chromosomal mapping of beta globin and albino loci in the domestic cat: A conserved mammalian chromosome group. J. Hered. 77: 374-378, 1986.
  112. O’Brien, S.J.: Molecular genetics in the domestic cat and its relatives. Trends Genet. 2:137-142, 1986.
  113. O’Brien, S.J., Collier, G. E., Benveniste, R. E., Nash, W. G., Newman, A. K., Simonson, J. M., Eichelberger, M. A., Seal, U. S., Bush, M., and Wildt, D. E.: Setting the molecular clock in Felidae: The great cats, Panthera. In Tilson, R. L. and Seal, U. S. (Eds.): Tigers of the World: The Biology, Biopolitics, Management and Conservation of an Endangered Species. Park Ridge, New Jersey, Noyes Publications, 1987, pp. 10-27.
  114. O’Brien, S.J., Wildt, D. E., Bush, M., Caro, T. M., FitzGibbon, C., Aggundey, I., and Leakey, R. E.: East African cheetahs: Evidence for two population bottlenecks? Proc. Natl. Acad. Sci. USA 84: 508-511, 1987.
  115. Goldman, D., Rathna Giri, P., and O’Brien, S.J.: Molecular genetic-distance estimates among the Ursidae as indicated by one- and two-dimensional protein electrophoresis. Evolution 43: 282-295, 1989.
  116. Park, M., Dean, M., Cooper, C. S., Schmidt, M., O’Brien, S.J., Blair, D. G., and Vande Woude, G. F.: Mechanism of met oncogene activation. Cell 45: 895-904, 1986.
  117. Jaye, M., Howk, R., Burgess, W., Ricca, G. A., Chiu, I. M., Ravera, M. W., O’Brien, S.J., Modi, W. S., Maciag, T., and Drohan, W. N.: Human endothelial cell growth factor: Cloning, nucleotide sequence, and chromosome localization. Science 233: 541-545, 1986.
  118. Schuchman, E. H., O’Brien, S.J., and Desnick, R. J.: Assignment of the feline alpha-L-iduronidase gene to chromosome D4. Genomics 4: 442-444, 1989.
  119. Papas, T. S., Watson, D. K., Sacchi, N., O’Brien, S.J., and Ascione, R.: The cellular ets genes: Molecular biology and clinical implications in human leukemias. Cancer Invest. 4: 555-574, 1986.
  120. Watson, D. K., Sacchi, N., McWilliams Smith, M. J., O’Brien, S.J., and Papas, T. S.: The avian and mammalian ets genes: Molecular characterization, chromosome mapping, and implication in human leukemia. Anticancer Res. 6: 631-636, 1986.
  121. Papas, T. S., Watson, D. K., Sacchi, N., O’Brien, S., and Ascione, R.: The cellular ets genes: Molecular probes in human neoplasia. Haematologica 72(Suppl): 6-18, 1987.
  122. Wayne, R. K., Nash, W. G., and O’Brien, S.J.: Chromosomal evolution of the Canidae: I. Species with high diploid numbers. Cytogenet. Cell Genet. 44: 123-133, 1987.
  123. Wayne, R. K., Nash, W. G., and O’Brien, S.J.: Chromosomal evolution of the Canidae: II. Divergence from the primitive carnivore karyotype. Cytogenet. Cell Genet. 44: 134-141, 1987.
  124. Hentze, M. W., Keim, S., Papadopoulos, P., O’Brien, S.J., Modi, W. S., Drysdale, J., Leonard, W. J., Harford, J. B., and Klausner, R. D.: Cloning, characterization, expression, and chromosomal localization of a human ferritin heavy-chain gene. Proc. Natl. Acad. Sci. USA 83: 7226-7230, 1986.
  125. Anagnou, N. P., Antonarakis, S. E., O’Brien, S.J., Modi, W. S., and Nienhuis, A. W.: Chromosomal localization and racial distribution of the polymorphic human dihydrofolate reductase pseudogene (DHFRP1). Am. J. Hum. Genet. 42: 345-352, 1988.
  126. Papas, T. S., Watson, D. K., Sacchi, N., O’Brien, S.J., and Ascione, R.: Molecular evolution of ets genes from avians to mammals and their cytogenetic localization to regions involved in leukemia. Gene Amplif Anal. 4: 207-238, 1986.
  127. Wildt, D. E., O’Brien, S.J., Howard, J. G., Caro, T. M., Roelke, M. E., Brown, J. L., and Bush, M.: Similarity in ejaculate-endocrine characteristics in captive versus free-ranging cheetahs of two subspecies. Biol. Reprod. 36: 351-360, 1987.
  128. O’Brien, S.J., Martenson, J. S., Packer, C., Herbst, L., de Vos, V., Joslin, P., Ott-Joslin, J., Wildt, D. E., and Bush, M.: Biochemical genetic variation in geographic isolates of African and Asiatic lions. Natl. Geo. Res. 3: 114-124, 1987.
  129. O’Brien, S.J., Joslin, P., Smith, G. L., III, Wolfe, R., Schaffer, N., Heath, E., Ott-Joslin, J., Rawal, P. P., Bhattacherjee, K. K., and Martenson, J. S.: Evidence for African origins of founders of the Asiatic lion species survival plan. Zoo Biol. 6: 99-116, 1987.
  130. Modi, W. S., Nash, W. G., Ferrari, A. C., and O’Brien, S.J.: Cytogenetic methodologies for gene mapping and comparative analyses in mammalian cell culture systems. Gene Anal. Tech. 4: 75-85, 1987.
  131. Wayne, R. K., Benveniste, R. E., Janczewski, D. N., and O’Brien, S.J.: Molecular and biochemical evolution of the Carnivora. In Gittleman, J. L. (Ed.): Carnivore Behavior, Ecology and Evolution. New York, Cornell University, 1989, pp. 465-494.
  132. Kinzler, K. W., Bigner, S. H., Bigner, D. D., Trent, J. M., Law, M. L., O’Brien, S.J., Wong, A. J., and Vogelstein, B.: Identification of an amplified highly expressed gene in a human glioma. Science 236: 70-73, 1987.
  133. Epstein, N. D., Karlsson, S., O’Brien, S., Modi, W., Moulton, A., and Nienhuis, A. W.: A new moderately repetitive DNA sequence family of novel organization. Nucleic Acids Res. 15: 2327-2341, 1987.
  134. Wildt, D. E., Bush, M., Goodrowe, K. L., Packer, C. Pusey, A. E., Brown, J. L., Joslin, P., and O’Brien, S.J.: Reproductive and genetic consequences of founding isolated lion populations. Nature 329: 328-331, 1987.
  135. Modi, W. S., Wayne, R. K., and O’Brien, S.J.: Analysis of fluctuating asymmetry in cheetahs. Evolution 41: 227-228, 1987.
  136. Wayne, R. K. and O’Brien, S.J.: Allozyme divergence within the Canidae. Syst. Zool. 36: 339-355, 1987.
  137. Nash, W. G. and O’Brien, S.J.: A comparative chromosome banding analysis of the Ursidae and their relationship to other Carnivores. Cytogenet. Cell Genet. 45: 206-212, 1987.
  138. Killen, P. D., Francomano, C. A., Yamada, Y., Modi, W. S., and O’Brien, S.J.: Partial structure of the human alpha 2(IV) collagen chain and chromosomal localization of the gene (COL4A2). Hum. Genet. 77: 318-324, 1987.
  139. O’Brien, S.J. and Knight, J. A.: The future of the giant panda. Nature 325: 758-759, 1987.
  140. O’Brien, S.J.: The ancestry of the giant panda. Sci. Am. 257: 102-107, 1987.
  141. O’Brien, S.J., Martenson, J. S., Eichelberger, M. A., Thorne, E. T., and Wright, F. W.: Genetic variation and molecular systematics of the black-footed ferret. In Seal, U. S., Thorne, E. T., Bogan, M. A., and Anderson, S. H. (Eds.): Conservation Biology and the Black-Footed Ferret. New Haven, Yale University, 1989, pp. 21-23.
  142. Yuhki, N. and O’Brien, S.J.: Molecular characterization and genetic mapping of class I and class II MHC genes of the domestic cat. Immunogenetics 27: 414-425, 1988.
  143. Marker, L. and O’Brien, S.J.: Captive breeding of the cheetah (Acinonyx jubatus) in North American Zoos (1871-1985). Zoo Biol. 8: 3-16, 1989.
  144. Kamholz, J., Spielman, R., Gogolin, K., Modi, W., O’Brien, S., and Lazzarini, R.: The human myelin-basic-protein gene: Chromosomal localization and RFLP analysis. Am. J. Hum. Genet. 40: 365-373, 1987.
  145. el Awady, M. K., Kaplan, J. B., O’Brien, S.J., and Burk, R. D.: Molecular analysis of integrated human papillomavirus 16 sequences in the cervical cancer cell line SiHa. Virology 159: 389-398, 1987.
  146. Le Beau, M. M., Epstein, N. D., O’Brien, S.J., Nienhuis, A. W., Yang, Y.-C., Clark, S. C., and Rowley, J. D.: The interleukin 3 gene is located on human chromosome 5 and is deleted in myeloid leukemias with a deletion of 5q. Proc. Natl. Acad. Sci. USA 84: 5913-5917, 1987.
  147. Jaye, M., Modi, W. S., Ricca, G. A., Mudd, R., Chiu, I.-M., O’Brien, S.J., and Drohan, W. N.: Isolation of a cDNA clone for the human laminin-B1 chain and its gene localization. Am. J. Hum. Genet. 41: 605-615, 1987.
  148. Dean, M., Kozak, C., Robbins, J., Callahan, R., O’Brien, S., and Vande Woude, G. F.: Chromosomal localization of the met proto-oncogene in the mouse and cat genome. Genomics 1:167-173, 1987.
  149. Graninger, W. B., Goldman, P. L., Morton, C. C., O’Brien, S.J., and Korsmeyer, S.J.: The kappa deleting element: Germline and rearranged, duplicated and dispersed forms. J Exp Med 167:488-501, 1988.
  150. Modi, W. S. and O’Brien, S.J.: Quantitative cladistic analyses of chromosomal banding data among species in three orders of mammals: Hominoid primates, felids and arvicolid rodents. In Gustafson, J. P. and Appels, R. (Eds.): Chromosome Structure and Function. New York, Plenum, 1988, pp. 215-242.
  151. Goodrowe, K. L., Wall, R. J., O’Brien, S.J., Schmidt, P. M., and Wildt, D. E.: Developmental competence of domestic cat follicular oocytes after fertilization in vitro. Biol. Reprod. 39:355-372, 1988.
  152. Lalley, P. A., O’Brien, S.J., Creau-Goldberg, N., Davisson, M. T., Roderick, T. H., Echard, G., Womack, J. E., Graves, J. M., Doolittle, D. P., and Guidi, J. N.: Report of the committee on comparative mapping. Human Gene Mapping 9. Cytogenet. Cell Genet. 46:367-389, 1987.
  153. Gilbert, D. A., O’Brien, J. S. and O’Brien, S.J.: Chromosomal mapping of lysosomal enzyme structural genes in the domestic cat. Genomics 2: 329-336, 1988.
  154. Modi, W. S., Masuda, A., Yamada, M., Oppenheim, J. J., Matsushima, K., and O’Brien, S.J.: Chromosomal localization of the human interleukin 1alpha (IL-1 alpha) gene. Genomics 2: 310-314, 1988.
  155. O’Brien, S.J. and Evermann, J. F.: Interactive influence of infectious disease and genetic diversity in natural populations. Trends Ecol. Evol. 3: 254-259, 1988.
  156. Yuhki, N., Heidecker, G. F., and O’Brien, S.J.: Characterization of MHC cDNA clones in the domestic cat: Diversity and evolution of class I genes. J. Immunol. 142: 3676-3682, 1989.
  157. Fanning, T. G., Modi, W. S., Wayne, R. K., and O’Brien, S.J.: Evolution of heterochromatin-associated satellite DNA loci in felids and canids (Carnivora). Cytogenet. Cell Genet. 48: 214-219, 1988.
  158. Modi, W. S., Fanning, T. G., Wayne, R. K., and O’Brien, S.J.: Chromosomal localization of satellite DNA sequences among 22 species of felids and canids (Carnivora). Cytogenet. Cell Genet. 48: 208-213, 1988.
  159. Ruppert, J. M., Kinzler, K. W., Wong, A.J., Bigner, S. H., Kao, F. T., Law, M. L., Seuanez, H., O’Brien, S.J., and Vogelstein, B.: The GLI-Kruppel family of human genes. Mol. Cell. Biol. 8: 3104-3113, 1988.
  160. Rao, V. N., Modi, W., Drabkin, H. D., Patterson, D., O’Brien, S.J., Papas, T.S., and Reddy, P.: The human erg gene maps to chromosome 21, band q22: relationship to the 8; 21 translocation of acute myelogenous leukemia. Oncogene 3: 497-500, 1988.
  161. O’Brien, S.J., Seuanez, H. N., and Womack, J.E.: Mammalian genome organization: An evolutionary view. In Campbell, A. (Ed.): Annual Review of Genetics, Vol. 22. Palo Alto, Annual Reviews Inc., 1988, pp. 323-351.
  162. 162a. O’Brien, S.J.: Molecular biology and evolutionary theory: The giant panda’s closest relatives. In Hecht, M. K. (Ed.): Evolutionary Biology at the Crossroads: A Symposium at Queens College. New York, Queens College, 1989, pp. 89-116.
    162b. O’Brien, S.J., Benveniste, R. E., Nash, W. G., Martenson, J. S., Eichelberger, M. A., Wildt, D. E., Bush, M., Wayne, R. K., and Goldman, D.: Molecular biology and evolutionary theory: The giant panda’s closest relatives. In Warren, L. and Koprowski, H. (Eds.): New Perspectives on Evolution, New York, Wiley-Liss, 1991, pp. 225-250.
  163. Westerman, M., Janczewski, D.N., and O’Brien, S.J.: DNA-DNA hybridization studies and marsupial phylogeny. Aust. J. Zool. 37: 315-323, 1990.
  164. Wayne, R. K., Meyer, A., Lehman, N., Van Valkenburgh, B., Kat, P. W., Fuller, T. K., Girman, D., and O’Brien, S.J.: Large sequence divergence among mitochondrial DNA genotypes within populations of eastern African black-backed jackals. Proc. Natl. Acad. Sci. USA 87: 1772-1776, 1990.
  165. Weissman, A. M., Hou, D., Orloff, D. G., Modi, W. S., Seuanez, H., O’Brien, S.J., and Klausner, R. D.: Molecular cloning and chromosomal localization of the human T-cell receptor zeta chain: Distinction from the molecular CD3 complex. Proc. Natl. Acad. Sci. USA 85: 9709-9713, 1988.
  166. Winkler, C., Schultz, A., Cevario, S., and O’Brien, S.J.: Genetic characterization of FLA, the cat major histocompatibility complex. Proc. Natl. Acad. Sci. USA 86: 943-947, 1989.
  167. Wayne, R. K., Van Valkenburgh, B., Kat, P. W., Fuller, T. K., Johnson, W. E., and O’Brien, S.J.: Genetic and morphological divergence among sympatric canids. J. Hered. 80: 447-454, 1989.
  168. Miyake, Y., O’Brien, S.J., and Kaneda, Y.: Regional localization of rDNA gene on pig chromosome 10 by in situ hybridization. Nippon Juigaku Zasshi 50: 341-345, 1988.
  169. Evermann, J. F., Heeney, J. L., Roelke, M. E., McKeirnan, A. J., and O’Brien, S.J.: Biological and pathological consequences of feline infectious peritonitis virus infection in the cheetah. Arch. Virol. 102: 155-171, 1988.
  170. O’Brien, S.J. and Graves, J. A. M.: Geneticists converge on divergent mammals: An overview of comparative mammalian genetics. Aust. J. Zool. 37: 147-154, 1990.
  171. Giri, P.R., Krug, J. F., Kozak, C., Moretti, T., O’Brien, S.J., Seuanez, H. N., and Goldman, D.: Cloning and comparative mapping of a human class III (chi) alcohol dehydrogenase cDNA. Biochem. Biophys. Res. Commun. 164: 453-460, 1989.
  172. O’Brien, S.J.: Barbara Kuhn. J. Hered. 79:491, 1988.
  173. Rojko, J. L., Kociba, G. J., Abkowitz, J. L., Hamilton, K. L., Hardy, W. D. Jr., Ihle, J. N., and O’Brien, S.J.: Feline lymphomas: Immunological and cytochemical characterization. Cancer Res. 49:345-351, 1989.
  174. Evermann, J. F., Heeney, J. L., McKeirnan, A. J., and O’Brien, S.J.: Comparative features of a coronavirus isolated from a cheetah with feline infectious peritonitis. Virus Res. 13:15-27, 1989.
  175. Heeney J. L., Evermann, J. F., McKeirnan, A. J., Marker-Kraus, L., Roelke, M. E., Bush, M., Wildt, D. E., Meltzer, D. G., Colly, L., Lucas, J., Manton, V. J., Caro, T., O’Brien, S.J.: Prevalence and implications of feline coronavirus infections of captive and free-anging cheetahs (Acinonyx jubatus). J. Virol. 64: 1964-1972, 1990.
  176. Gilbert, D. A., Reid, Y. A., Gail, M. H., Pee, D., White, C., Hay, R. J., and O’Brien, S.J.: Application of DNA fingerprints for cell-line individualization. Am. J. Hum. Genet. 47: 499-514, 1990.
  177. Modi, W. S., Levine, M. A., Seuanez, H. N., Dean, M., and O’Brien, S.J.: The human chromogranin A gene: Chromosome assignment and RFLP analysis. Am J Hum Genet 45:814-818, 1989.
  178. Lalley, P. A., Davisson, M. T., Graves, J. A. M., O’Brien, S.J., Roderick, T. H., Doolittle, D. P., and Hillyard, A. L.: Report of the committee on comparative mapping. Human Gene Mapping 9.5: Update to the Ninth International Workshop on Human Gene Mapping. Cytogenet. Cell Genet. 49:227-235, 1988.
  179. Yuhki, N. and O’Brien, S.J.: DNA variation of the mammalian major histocompatibility complex reflects genomic diversity and population history. Proc. Natl. Acad. Sci. USA 87: 836-840, 1990.
  180. Mann, D.L., O’Brien, S.J., Gilbert, D.A., Reid, Y., Popovic, M., Read-Connole, E., Gallo, R. C., and Gazdar, A. F.: Origin of the HIV-susceptible human CD4+ cell line H9. AIDS Res. Hum. Retroviruses 5: 253-255, 1989.
  181. McGuire, E. A., Hockett, R. D., Pollock, K. M., Bartholdi, M. F., O’Brien, S.J., and Korsmeyer, S.J.: The t(11;14) (p15;q11) in a T-cell acute lymphoblastic leukemia cell line activates multiple transcripts including Ttg-1, a gene encoding a potential zinc finger protein. Mol. Cell. Biol. 9: 2124-2132, 1989.
  182. Anagnou, N. P., Economou-Pachnis, A., O’Brien, S.J., Modi, W. S., Nienhuis, A. W., and Tsichlis, P. N.: The human homolog of the Moloney leukemia virus integration 2 locus (MLV12) maps to band p14 of chromosome 5. Genomics 5: 354-358, 1989.
  183. Sack, G. H., Jr., Talbot, C. C., Seuanez, H., and O’Brien, S.J.: Molecular analysis of the human serum amyloid A (SAA) gene family. Scand. J. Immunol. 29: 113-119, 1989.
  184. Gardner, M. B., Kozak, C., and O’Brien, S.J.: The Lake Casitas wild mouse: Evolving genetic resistance to retroviral disease. Trends Genet. 7: 22-27, 1991.
  185. Mock, B., Kozak, C., Seldin, M. F., Ruff, N., D’Hoostelaere, L., Szpirer, C., Seuanez, H., O’Brien, S., and Banner, S.: A glutaminase (Gls) gene maps to mouse chromosome 1, rat chromosome 9 and human chromosome 2. Genomics 5: 291-297, 1989.
  186. Hentze, M. W., Seuanez, H. N., O’Brien, S.J., Harford, J. B., and Klausner, R. D.: Chromosomal localization of nucleic acid-binding proteins by affinity mapping: Assignment of the IRE-binding protein gene to human chromosome 9. Nucleic Acids Res. 17:6103-6108, 1989.
  187. Johnston, L. A., O’Brien, S.J., and Wildt, D. E.: In vitro maturation and fertilization of domestic cat follicular oocytes. Gamete Res. 24: 343-356, 1989.
  188. Reeves, R. H., Gearhart, J. D., Hecht, N. B., Yelick, P., Johnson, P., and O’Brien S.J.: Mapping of PRM-1 to human chromosome 16 and tight linkage of Prm-1 and Prm-2 on mouse chromosome 16. J. Hered. 80: 442-446, 1989.
  189. Winkler, C., Yuhki, N., and O’Brien, S.J.: Comparative analysis of FLA, the major histocompatibility complex in the Felidae. In Clegg, M. T., and O’Brien, S.J. (Eds.): Molecular Evolution. New York, Wiley, Liss, 1990, pp. 29-50.
  190. Yuhki, N., Winkler, C., and O’Brien, S.J.: MHC genes of the domestic cat. In Srivastava, R., Ram, B. P., and Tyle, P. (Eds.): Immunogenetics of the Major Histocompatibility Complex. New York, VCH Publishers, 1991, pp. 348-367.
  191. Lalley, P. A., Davisson, M. T., Graves, J. A. M., O’Brien, S.J., Womack, J. E., Roderick, T. H., Creau-Goldberg, N., Hillyard, A. L., Doolittle, D. P., and Rogers, J. A.: Report of the committee on comparative mapping. Human Gene Mapping 10. Cytogenet. Cell Genet. 51: 503-532, 1989.
  192. Modi, W. S., Seuanez, H. N., Jaye, M., Haigler, H. J., Kaplan, R., and O’Brien, S.J.: The human endonexin II (ENX2) gene is located at 4q28—-q32. Cytogenet. Cell Genet. 52:167-169, 1989.
  193. Modi, W. S., Dean, M., Seuanez, H. N., Mukadia, N., Matsushima, K., and O’Brien, S. J: Monocyte-derived neutrophil chemotatic factor (MDNCF/IL-8) resides in a gene cluster along with several other members of the platelet factor 4 gene superfamily. Hum. Genet. 84:185-187, 1990.
  194. Baker, C. S., Palumbi, S. R., Lambertsen, R. H., Weinrich, M. T., Calambokidis, J., and O’Brien, S.J.: Influence of seasonal migration on geographic distribution of mitochondrial DNA haplotypes in humpback whales. Nature 344:238-240, 1990.
  195. Janczewski, D. N., Goldman, D., and O’Brien, S.J.: Molecular genetic divergence of orang utan (Pongo pygmaeus) subspecies based on isozyme and two-dimensional gel electrophoresis. J. Hered. 81:375-387, 1990.
  196. Wayne, R. K., Van Valkenburgh, B., and O’Brien, S.J.: Molecular distance and divergence time in carnivores and primates. Mol. Biol. Evol. 8: 297-319, 1991.
  197. Yuhki, N. and O’Brien, S.J.: DNA recombination and natural selection pressure sustain genetic sequence diversity of the feline MHC class I genes. J. Exp. Med. 172: 621-630, 1990.
  198. Halverson, D., Modi, W., Dean, M., Gelman, E. P., Dunn, K. J., Clanton, D., Oskarsson, M., O’Brien, S.J., and Blair, D. G.: An oncogenic chromosome 8-9 gene fusion isolated following transfection of human ovarian carcinoma cell line DNA. Oncogene 5: 1085-1089, 1990.
  199. Bush, M., Graves, J. A. M., O’Brien, S.J., and Wildt, D. E.: Dissociative anaesthesia in free-ranging male koalas and selected marsupials in captivity. Aust. Vet. J. 67: 449-451, 1990.
  200. Gilbert, D. A., Lehman, N., O’Brien, S.J., and Wayne, R. K.: Genetic fingerprinting reflects population differentiation in the California Channel Island fox. Nature 344: 764-767, 1990.
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  202. Dionne, C. A., Kaplan, R., Seuanez, H., O’Brien, S.J., and Jaye, M.: Chromosome assignment by polymerase chain reaction techniques: Assignment of the oncogene FGF- to human chromosome 4. Biotechniques 8: 190-194, 1990.
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  204. Baker, C. S., Lambertsen, R. H., Weinrich, M. T., Calambokidis, J., Early, G., and O’Brien, S.J.: Molecular genetic identification of the sex of humpback whales (Megaptera novaeangliae). In Hoelzel, A. R. (Ed.): Genetic Ecology of Whales and Dolphins. Cambridge, International Whaling Committee, 1991, pp. 105-111.
  205. Levine, M. A., Modi, W. S., and O’Brien, S.J.: Chromosomal localization of the genes encoding two forms of the G-protein beta polypeptide, beta 1 and beta 3, in man. Genomics 8: 380-386, 1990.
  206. Brown, J. L., Bush, M., Packer, C., Pusey, A. E., Monfort, S. L., O’Brien, S.J., Janssen, D. L., and Wildt, D. E.: Developmental changes in pituitary-gonadal function in free-ranging lions (Panthera leo leo) of the Serengeti Plains and Ngorongoro Crater. J. Reprod. Fertil. 91: 29-40, 1991.
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  210. O’Brien, S.J.: The genetic peril of the cheetah. In Seidensticker, J. (Ed.): Great Cats: Majestic Creatures of the Wild. Sydney, Australia, Weldon Owen Pty Ltd., 1991, p. 18.
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  212. Miththapala, S., Seidensticker, J., Phillips, L. G., Goodrowe, K. L., Fernando, S. B. U., Forman, L., and O’Brien, S.J.: Genetic variation in Sri Lankan leopards. Zoo Biol. 10: 139-146, 1991.
  213. Goldman, D., O’Brien, S.J., Lucas-Derse, S., and Dean, M.: Linkage mapping of human polymorphic proteins identified by two-dimensional electrophoresis. Genomics 11: 875-884, 1991.
  214. Johnston, L. A., Donoghue A. M., O’Brien, S.J., and Wildt, D. E.: Culture medium and protein supplementation influence in vitro fertilization and embryo development in the domestic cat. J. Exp. Zool. 257: 350-359, 1991.
  215. Wildt, D. E., Bush, M., O’Brien, S.J., Murray, N. D., Taylor, A., and Graves, J. A. M.: Semen characteristics in free-living koalas (Phascolarctos cinereus). J. Reprod. Fertil. 92: 99-107, 1991.
  216. Johnston, L. A., Donoghue, A. M., O’Brien, S.J., and Wildt, D. E.: Influence of temperature and gas atmosphere on in vitro fertilization and embryo development in domestic cats. J. Reprod. Fertil. 92: 377-382, 1991.
  217. Packer, C., Pusey, A. E., Rowley, H., Gilbert, D. A., Martenson, J. S., and O’Brien, S.J.: Case study of a population bottleneck: Lions of the Ngorongoro Crater. Conservation Biology 5: 219-230, 1991.
  218. Gilbert, D. A., Packer, C., Pusey, A. E., Stephens, J. C., and O’Brien, S.J.: Analytical DNA fingerprinting in lions: Parentage, genetic diversity, and kinship. J. Hered. 82: 378-386, 1991.
  219. Packer, C., Gilbert, D. A., Pusey, A. E., and O’Brien, S.J.: Kinship, cooperation and inbreeding in African lions: A molecular genetic analysis. Nature 351: 562-565, 1991.
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  221. Poduslo, S. E., Dean, M., Kolch, U., and O’Brien, S.J.: Detecting high-resolution polymorphisms in human coding loci by combining PCR and single-strand conformation polymorphism (SSCP) analysis. Am. J. Hum. Genet. 49: 106-111, 1991.
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  223. O’Brien, S.J. and Mayr, E.: Bureaucratic mischief: Recognizing endangered species and subspecies. Science 251: 1187-1188, 1991.
  224. O’Brien, S.J.: Mammalian genome mapping: Lessons and prospects. Curr Opin Genet Dev 1: 105-111, 1991.
  225. Reid, Y. A., Gilbert, D. A., and O’Brien, S.J.: The use of DNA hypervariable probes for human cell line identification. ATCC Quarterly 10: 1-3, 1990.
  226. Masuda, R., Yuhki, N., and O’Brien, S.J.: Molecular cloning, chromosomal assignment, and nucleotide sequence of the feline homeobox HOX3A. Genomics 11: 1007-1013, 1991.
  227. Stephens, J. C., Gilbert, D. A., Yuhki, N., and O’Brien, S.J.: Estimation of heterozygosity for single-probe multilocus DNA fingerprints. Mol. Biol. Evol. 9: 729-743, 1992.
  228. Miller, M. D., Wilson, S. D., Dorf, M. E., Seuanez, H. N., O’Brien, S.J., and Krangel, M. S.: Sequence and chromosomal location of the I-309 gene: Relationship to genes encoding a family of inflammatory cytokines. J. Immunol. 145: 2737-2744, 1990.
  229. Levine, M. A., Modi, W. S., and O’Brien, S.J.: Mapping of the gene encoding the alpha subunit of the stimulatory G protein of adenylyl cyclase (GNAS1) to 20q13.2—-q13.3 in human by in situ hybridization. Genomics 11: 478-479, 1991.
  230. Johnston, L.A., Donoghue, A.M., O’Brien, S.J., and Wildt, D.E.: Rescue and maturation in vitro of follicular oocytes from nondomestic felid species. Biol. Reprod. 45: 898-906, 1991.
  231. Dean, M., Lucas-Derse, S., Bolos, A., O’Brien, S.J., Kirkness, E. F., Fraser, C. M., and Goldman, D.: Genetic mapping of the beta 1 GABA receptor gene to human chromosome 4 using a tetranucleotide repeat polymorphism. Am J Hum Genet 49: 621-626, 1991.
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  234. White, M.B., Carvalho, M., Derse, D., O’Brien, S.J., and Dean, M.: Detecting single base substitutions as heteroduplex polymorphisms. Genomics 12: 301-306, 1992.
  235. Goldman, D. and O’Brien, S.J.: Two-dimensional protein electrophoresis in phylogenetic studies. Meth. Enzymol. 244:113-121, 1993.
  236. Dionne, C. A., Modi, W. S., Crumley, G., O’Brien, S.J., Schlessinger, J., and Jaye, M.: BEK, a receptor for multiple members of the fibroblast growth factor (FGF) family, maps to human chromosome 10q25.3—-10q26. Cytogenet. Cell Genet. 60: 34-36, 1992.
  237. Baker, C.S., Gilbert, D.A., Weinrich, M.T., Lambertsen, R., Calmabokidis, J., McArdle, B., Chambers, G. K., and O’Brien, S.J.: Population characteristics of DNA fingerprints in humpback whales (Megaptera novaeangliae). J. Hered. 84: 281-290, 1993.
  238. O’Brien, S.J.: Genetic erosion: A global dilemma. Natl. Geogr. 181: 136, 1992.
  239. O’Brien, S.J.: Ghetto legacy. Can the high incidence of Tay-Sachs disease in Ashkenazi Jews be linked to historic epidemics of tuberculosis in industrial European cities? Current Biology 1: 209-211, 1991.
  240. O’Brien, S.J.: Fuzzy thinking about the giant panda’s ancestry. In Stirling, I. (Ed.): Bears. Sydney, Australia, Weldon Owen Pty. Ltd., 1993, pp. 34-35.
  241. Janczewski, D. N., Yuhki, N., Gilbert, D. A., Jefferson, G. T., and O’Brien, S.J.: Molecular phylogenetic inference from saber-toothed cat fossils of Rancho La Brea. Proc. Natl. Acad. Sci. USA. 89: 9769-9773, 1992.
  242. Lautenberger, J. A., Burdett, L. A., Gunnell, M., Qi, S., Watson, D. K., O’Brien, S.J., and Papas, T. S.: Genomic dispersal of the ets gene family during metazoan evolution. Oncogene 7: 1713-1719, 1992.
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  244. Hoelzel, A. R., Halley, J., O’Brien, S.J., Campagna, C., Arnbom, T., Le Boeuf, B., Ralls, K., and Dover, G. A.: Elephant seal genetic variation and the use of simulation models to investigate historical population bottlenecks. J. Hered. 84:443-449, 1993.
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  246. Jackson, C. E., Yuhki, N., Desnick, R. J., Haskins, M. E., O’Brien, S.J., and Schuchman, E. H.: Feline arylsulfatase B (ARSB): Isolation and expression of the cDNA, comparison with human ARSB, and gene localization to feline chromosome A1. Genomics 14: 403-411, 1992.
  247. O’Brien S.J. and Mann, D. L.: Adaptive chaos and AIDS. Current Biology 2: 203-205, 1992.
  248. O’Brien, S.J.: The molecular evolution of the bears. In Stirling, I. (Ed.): Bears. Sydney, Australia, Weldon Owen Pty. Ltd., 1993, pp. 26-33.
  249. Kelley, M. J., Pech, M., Seuanez, H. N., Rubin, J. S., O’Brien, S.J., and Aaronson, S. A.: Emergence of the keratinocyte growth factor multigene family during the great ape radiation. Proc. Natl. Acad. Sci. USA 89: 9287-9291, 1992.
  250. Donoghue, A. M., Johnston, L. A., Goodrowe, K. L., O’Brien, S.J. and Wildt, D. E.: Influence of day of estrous on egg viability and comparative efficiency of in vitro fertilization in domestic cats in natural or gonadotrophin-induced oestrus. J. Reprod. Fertil. 98: 85-90, 1993.
  251. Menotti-Raymond, M. and O’Brien, S.J.: Dating the genetic bottleneck of the African cheetah. Proc. Natl. Acad. Sci. USA 90: 3172-3176, 1993.
  252. O’Brien, S.J., Womack, J. E., Lyons, L. A., Moore, K. J., Jenkins, N. A., and Copeland, N. G.: Anchored reference loci for comparative genome mapping in mammals. Nature Genet. 3: 103-112, 1993.
  253. Roelke, M. E., Martenson, J. S. and O’Brien, S.J.: The consequences of demographic reduction and genetic depletion in the endangered Florida panther. Curr. Biol. 3: 340-350, 1993.
  254. Brown, E. W., Olmsted, R. A., Martenson, J. S., and O’Brien, S.J.: Exposure to FIV and FIPV in wild and captive cheetahs. Zoo Biol. 12: 135-142, 1993.
  255. Briscoe, D., Stephens, J. C., and O’Brien, S.J.: Linkage disequilibrium in admixed populations: Applications in gene mapping. J. Hered. 85: 59-63, 1994.
  256. Johnston, L. A., Donoghue, A. M., O’Brien, S.J., and Wildt, D. E.: Influence of culture medium on in vitro maturation and fertilization in the domestic cat. Theriogenology 80: 829-839, 1993.
  257. Brown, E. W., Miththapala, S. and O’Brien, S.J.: Prevalence of exposure to feline immunodeficiency virus in exotic felid species. J. Zoo Wildl. Med. 24: 357-364, 1993.
  258. Baker, C. S., Perry, A., Bannister, J. L., Weinrich, M. T., Abernethy, R. B., Calambokidis, J., Lien, J., Lambertsen, R. H., Urban Ramirez, J., Vasquez, O., Clapham, P. J., Alling, A., O’Brien, S.J., and Palumbi, S. R.: Abundant mitochondrial DNA variation and world-wide population structure in humpback whales. Proc. Natl. Acad. Sci. USA 90: 8239-8243, 1993.
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  262. Yuhki, N. and O’Brien, S.J.: Exchanges of short polymorphic DNA segments predating speciation in feline major histocompatibility complex class I genes. J Mol Evol 39:22-33, 1994.
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  266. Lopez, J. V., Yuhki, N., Masuda, R., Modi, W. S., and O’Brien, S.J.: Numt, a recent transfer and tandem amplification of mitochondrial DNA to the nuclear genome of the domestic cat. J. Mol. Evol. 39:174-190, 1994.
  267. Brown, J.L., Bush, M., Packer, C., Pusey, A.E., Monfort, S.L., O’Brien, S.J., Janssen, D.L., and Wildt, D. E.: Hormonal characteristics of free-ranging female lions (Panthera leo) of the Serengeti Plains and Ngorongoro Crater. J. Reprod. Fertil. 97: 107-114, 1993.
  268. Glavac, D., Ravnik-Glavac, M., O’Brien, S.J., and Dean, M.: Polymorphisms in the 3′ untranslated region of the I kappa B/MAD-3 (NFKBI) gene located on chromosome 14. Hum. Genet. 93: 694-696, 1994.
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  270. Okuda, M., Umeda, A., Matsumoto, Y., Momoi, Y., Watari, T., Goitsuka, R., O’Brien, S.J., Tsujimoto, H., and Hasegawa, A.: Molecular cloning and chromosomal mapping of feline p53 tumor suppressor gene. J. Vet. Med. Sci. 55: 801-805, 1993.
  271. Tsujimoto, H., Fulton, R., Nishigaki, K., Matsumoto, Y., Hasegawa, A., Cevario, S., O’Brien, S.J., Terry, A., Onions, D., and Neil, J. C.: A common proviral integration region, fit-1, in T-cell tumors induced by Myc-containing feline leukemia viruses. Virology 196: 845-848, 1993.
  272. Seuanez, H. N., Alves, G., and O’Brien, S.J.: Genetic characterization of parental cell lines and biochemical analysis of somatic cell hybrids between mouse (RAG) cells and fibroblasts of Ateles paniscus chamek (Primates, Platyrrhini). Am. J. Primatol. 30: 181-194, 1993.
  273. Langley, R. J., Hirsch, V. M., O’Brien, S.J., Adger-Johnson, D., Goeken, R. M., and Olmsted, R. A.: Nucleotide sequence analysis of puma lentivirus (PLV-14): Genomic organization and relationship to other lentiviruses. Virology 202: 853-864, 1994.
  274. Pecon-Slattery, J., Johnson, W. E., Goldman, D., and O’Brien, S.J.: Phylogenetic reconstruction of South American felids defined by protein electrophoresis. J. Mol. Evol. 39: 296-305, 1994.
  275. Miththapala, S., Seidensticker, J., and O’Brien, S.J.: Phylogeographic subspecies recognition in leopards (Panthera pardus): Molecular genetic variation. Conserv. Biol. 10: 1115-1132, 1996.
  276. Anagnou, N. P., Seuanez, H., Modi, W., O’Brien, S.J., Papamatheakis, J., and Moschonas, N. K.: Chromosomal mapping of two members of the human glutamate dehydrogenase (GLUD) gene family to chromosomes 10q22.3-q23 and Xq22-q23. Hum. Hered. 43: 351-356, 1993.
  277. O’Brien, S.J.: Perspective on conservation genetics. In Schierwater, B., Streit, B., Wagner, G. P., and DeSalle, R. (Eds.): Molecular Ecology and Evolution: Approaches and Applications. Basel, Birkhauser Verlag, 1994, pp. 275-280.
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  279. O’Brien, S.J., Lu, Z., Knight, J., Qui, X., Mainka, S., and Pan, W.: Conservation genetics with respect to giant pandas. Proc. Int. Giant Panda Conserv. Symp. Cheng Du, China, pp. 112-115, 1994.
  280. Stephens, J. C., Briscoe, D., and O’Brien, S.J.: Mapping by admixture linkage disequilibrium (MALD) in human populations: Limits and guidelines. Am. J. Hum. Genet. 55: 809-824, 1994.
  281. Brown, E. W., Yuhki, N., Packer, C., and O’Brien, S.J.: A lion lentivirus related to feline immunodeficiency virus: Epidemiologic and phylogenetic aspects. J Virol 68:5953-5968, 1994.
  282. O’Brien, S.J.: The big cats tell a new story about the endangered species. Cosmos 4:14-18, 1994.
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  284. Hoelzel, A. R., Lopez, J. V., Dover, G. A., and O’Brien, S.J.: Rapid evolution of a heteroplasmic repetitive sequence in the mitochondrial DNA control region of carnivores. J Mol Evol 39: 191-199, 1994.
  285. O’Brien, S.J. and Clegg, M. T.: Genomes and evolution. Curr. Opin. Genet. Dev. 3: 835-836, 1993.
  286. O’Brien, S.J., Peters, J., Searle, A.G., Womack, J.E., Johnson, P.A., and Graves, J.A. M.: Comparative gene mapping committee report. In Cuticchia, A.J. and Pearson, P. L. (Eds.): Human Gene Mapping, 1993: A Compendium. Baltimore, Johns Hopkins University Press, 1994, pp. 846-892.
  287. Pecon Slattery, J. and O’Brien, S.J.: Molecular phylogeny of the red panda (Ailurus fulgens). J. Hered. 86: 413-422, 1995.
  288. Seuanez, H.N., Alves, G., and O’Brien, S.J.: Gene mapping in the spider monkey (Ateles paniscus chamek). J. Hered. 85: 466-473, 1994.
  289. Jordan, K., O’Brien, S.J., Johnson, K.H., and O’Brien, T.D.: Assignment of islet amyloid polypeptide (IAPP) gene to feline chromosome B4 using the polymerase chain reaction technique on feline-rodent hybrid cell lines. Vet. Pathol. 32: 195-197, 1995.
  290. Dean, M., Stephens, J. C., Winkler, C., Lomb, D. A., Ramsburg, M., Boaze, R., Stewart, C., Charbonneau, L., Goldman, D., Albaugh, B. J., Goedert, J. J., Beasley, R. P., Hwang, L.-Y., Buchbinder, S., Weedon, M., Johnson, P. A., Eichelberger, M., and O’Brien, S.J.: Polymorphic admixture typing in human ethnic populations. Am. J. Hum. Genet. 55: 788-808, 1994.
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  295. Sundberg, J.P., Montali, R.J., Bush, M., Phillips, L.G., Jr., O’Brien, S.J., Jenson, A. B., Burk, R.D., and Van Ranst, M.: Papillomavirus-associated focal oral hyperplasia in wild and captive Asian lions (Panthera leo persica). J. Zoo Wildl. Med. 27: 61-70, 1996.
  296. Lyons, L. A., Raymond, M. M., and O’Brien, S.J.: Comparative genomics: The next generation. Animal Biotechnology 5: 103-111, 1994.
  297. Menotti-Raymond, M. A. and O’Brien, S.J.: Evolutionary conservation of ten microsatellite loci in four species of Felidae. J. Hered. 86: 319-322, 1995.
  298. Waits, L. P., Sullivan, J., O’Brien, S.J., and Ward, R. H.: Rapid radiation events in the family Ursidae indicated by likelihood phylogenetic estimation from multiple fragments of mtDNA. Mol. Phylogenet. Evol. 13: 82-92, 1999.
  299. Dratch, P.A., Roslund, W., Martenson, J.S., Greenwell, R., O’Brien, S.J., and Best, T.: Molecular genetic identification of the Mexican onza as a puma (Felis concolor). Cryptozoology 12: 42-49, 1993-1996.
  300. O’Brien, S.J.: Genetic and phylogenetic analyses of endangered species. Ann. Rev. Genet. 28: 467-489, 1994.
  301. Carpenter, M.A., O’Brien, S.J.: Coadaptation and immunodeficiency virus: Lessons from the Felidae. Curr. Opin. Genet. Devel. 5: 739-745, 1995.
  302. Alexander, K.A., MacLachlan, N.J., Kat, P.W., House, C., O’Brien, S.J., Lerche, N. W., Sawyer, M., Frank, L.G., Holekamp, K., Smale, L., McNutt, J. W., Laurenson, M.K., Mills, M.G.L., and Osburn, B.I.: Evidence of natural bluetongue virus infection among African carnivores. Am. J. Trop. Med. Hyg. 51: 568-576, 1994.
  303. Wienberg, J., Stanyon, R., Nash, W.G., O’Brien, P.C.M., Yang, F., O’Brien, S.J., and Ferguson-Smith, M.A.: Conservation of human vs. feline genome organization revealed by reciprocal chromosome painting. Cytogenet. Cell Genet. 77: 211-217, 1997.
  304. Kaslow, R.A., Carrington, M., Apple, R., Park, L., Munoz, A., Saah, A.J., Goedert, J.J., Winkler, C., O’Brien, S.J., Rinaldo, C., Detels, R., Blattner, W., Phair, J., Erlich, H., and Mann, D.L.: Influence of combinations of human major histocompatibility complex genes on the course of HIV-1 infection. Nature Med. 2: 405-411, 1996.
  305. Lopez, J.V., Cevario, S., and O’Brien, S.J.: Complete nucleotide sequence of the domestic cat (Felis catus) mitochondrial genome and a transposed mtDNA tandem repeat (Numt) in the nuclear genome. Genomics 33: 229-246, 1996.
  306. Menotti-Raymond, M. and O’Brien, S.J.: Hypervariable genomic variation to reconstruct the natural history of populations: Lessons from the big cats. Electrophoresis 16: 1771-1774, 1995.
  307. Lyons, L.A. and O’Brien, S.J.: Comparative gene mapping for the feline genome project. Strategies 9: 77-78, 1996.
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  396. Murphy, W. J., Stanyon, R., and O’Brien, S.J.: Evolution of mammalian genome organization inferred from comparative gene mapping. Genome Biol. 2: Reviews 0005.1-0005.8, 2001.
  397. Greenough, T. C., Brettler, D. B., Kirchhoff, F., Alexander, L., Desrosiers, R. C., O’Brien, S.J., Somasundaran, M., Luzuriaga, K., and Sullivan, J. L.: Long-term nonprogressive infection with human immunodeficiency virus type 1 in a hemophilia cohort. J. Infect. Dis. 180: 1790-1802, 1999.
  398. Bream, J. H., Young, H. A., Rice, N., Martin, M. P., Carrington, M., and O’Brien, S.J.: CCR5 promoter alleles and specific DNA binding factors. Science. 284: 223a, 1999.
  399. Lautenberger, J. A., Stephens, J. C., O’Brien, S.J., and Smith, M. W.: Significant admixture linkage disequilibrium across 30 cM around the FY locus in African Americans. Am. J. Hum. Genet. 66: 969-978, 2000.
  400. Shin, H. D., Winkler, C., Bream, J., Young, H., Phair, J., Goedert, J. J., Vlahov, D., Buchbinder, S., Donfield, S., O’Brien, S.J., and Smith, M. W.: Genetic restriction of HIV-1 pathogenesis to AIDS by promoter alleles of IL10. Proc. Natl. Acad. Sci. USA. 97: 14467-14472, 2000.
  401. O’Brien, S.J., Dean, M., Smith, M. W., Winkler, C., Nelson, G. W., Martin, M. P., and Carrington, M.: The human genes that limit AIDS. In Boulyjenkov, V., Berg, K., and Christen, Y. (Eds.): Genes and Resistance to Disease. Heidelberg, Springer Verlag, 2000, pp. 9-17.
  402. An, P., Martin, M. P., Nelson, G., Carrington, M., Smith, M. W., Gong, Q., Vlahov, D., Phair, J., O’Brien, T., Goedert, J., Buchbinder, S., O’Brien, S.J., and Winkler, C. A.: Influence of CCR5 promoter haplotypes on AIDS progression in African Americans. AIDS 14: 2117-2122, 2000.
  403. Culver, M., Johnson, W. E., Pecon Slattery, J., and O’Brien, S.J.: Genomic ancestry of the American puma (Puma concolor). J. Hered. 91: 186-197, 2000.
  404. Carrington, M., Dean, M., Martin, M. P., O’Brien, S.J.: Genetics of HIV-1 infection: chemokine receptor CCR5 polymorphism and its consequences. Hum. Mol. Genet. 8: 1939-1945, 1999.
  405. Murphy, W. J., Sun, S., Chen, Z.-Q., Pecon Slattery, J., and O’Brien, S.J.: Extensive conservation of sex chromosome organization between cat and human revealed by parallel radiation hybrid mapping. Genome Res. 9: 1223-1230, 1999.
  406. Caetano, A. R., Shiue, Y.-L., Lyons, L. A., O’ Brien, S.J., Laughlin, T. F., Bowling, A. T., and Murray, J. D.: A comparative gene map of the horse (Equus caballus). Genome Res. 9: 1239-1249, 1999.
  407. Driscoll, C. A., Menotti-Raymond, M., and O’Brien, S.J.: Genomic microsatellites as evolutionary chronometers: A test in wild cats. Genome Res. 12: 414-423, 2002.
  408. Winkler, C. A. and O’Brien, S.J.: AIDS restriction genes in human ethnic groups: An assessment. In Essex, M., Mboup, S., Kanki, P. J., Marlink, R., and Tlou, S. D. (Eds.): AIDS in Africa, Second Edition, New York, Kluwer Academic. New York. pp. 52-73, 2002.
  409. O’Brien, S.J. and Carrington, M.: Selection against susceptibility to HIV-1. Science 285: 11a, 1999.
  410. O’Brien, S.J., Menotti-Raymond, M., Murphy, W. J., Nash, W. G., Wienberg, J., Stanyon, R., Copeland, N. G., Jenkins, N. A., Womack, J. E., and Marshall Graves, J. A.: The promise of comparative genomics in mammals. Science 286: 458-481, 1999.
  411. Sheppard, H., Celum, C., Michael, N., O’Brien, S.J., Carrington, M., Dondero, D., Buchbinder, S.: HIV-1 infection in individuals with the CCR5-Δ32/Δ32 genotype: Acquisition of syncytium-inducing virus at seroconversion. J. AIDS 29:307-313, 2002.
  412. Alexander, L., Weiskopf, E., Greenough, T. C., Gaddis, N. C., Auerbach, M. R., Malim, M. H., O’Brien, S.J., Walker, B. D., Sullivan, J. L., and Desrosiers, R. C.: Unusual polymorphisms in human immunodeficiency virus type 1 associated with nonprogressive infection. J. Virol.74: 4361-4376, 2000.
  413. Culver, M., Raymond, M. A., and O’Brien, S.J.: Patterns of size homoplasy at 10 microsatellite loci in pumas (Puma concolor). Mol. Biol. Evol. 18: 1151-1156, 2001.
  414. Munson, L., Marker, L., Dubovi, E., Spencer, J.A., Evermann, J.F., and O’Brien, S.J.: Serosurvey of viral infections in free-ranging Namibian cheetahs (Acinonyx jubatus). J. Wildlife Dis. 40:23-31, 2004.
  415. Martínez-Cruz, B. David, V.A., Godoy, J.A. Negro, J. J., O’Brien, S.J., Johnson, W.E. Eighteen polymorphic microsatellite markers for the highly endangered Spanish Imperial Eagle (Aquila adalberti) and related species. Molecular Ecology 2:323-326. 2002.
  416. Murphy, W. J., Sun, S., Chen, Z.-Q., Yuhki, N., Hirschmann, D., Menotti-Raymond, M., and O’Brien, S.J.: A radiation hybrid map of the cat genome: Implications for comparative mapping. Genome Res. 10: 691-702, 2000.
  417. O’Brien, S.J., Lander, E.S., Haskins, M., Giger, U., Pederson, N.C., Wildt, D., Murphy, W.J., Yuhki, N., and Menotti-Raymond, M. NHGRI White Paper, Sequencing the genome of the domestic cat, Felis catus. http://www.genome.gov/Pages/Research/Sequencing/SeqProposals/CatSEQ.pdf
  418. Sarno, R. J., Franklin, W. L., O’Brien, S.J., and Johnson, W. E.: Patterns of mtDNA and microsatellite variation in an island and mainland population of guanacos in southern Chile. Animal Conservation. 4:93-101, 2001.
  419. O’Brien, S.J.: Adaptive cycles: Parasites selectively reduce inbreeding in Soay sheep. Trends Ecol. Evol. 15: 7-9, 2000.
  420. O’Brien, S.J. and Stanyon, R.: Phylogenomics: Ancestral primate viewed. Nature. 402: 365-366, 1999.
  421. Pecon Slattery, J., Murphy, W. J., and O’Brien, S.J.: Patterns of diversity among SINE elements isolated from three Y-chromosome genes in carnivores. Mol. Biol. Evol. 17: 825-829, 2000.
  422. O’Brien, S.J., Gallo, R., and Essex, M.: Remembering Takis Papas. Cancer Res. 60: Cover Legend, October 15, 2000.
  423. Daar, E. S., Lynn, H., Donfield, S., Gomperts, E., O’Brien, S.J., Hilgartner, M. W., Hoots, W. K., Chernoff, D., Arkin, S., Wong, W.-Y., Winkler, C. A., and the Hemophilia Growth and Development Study: Hepatitis C virus load is associated with human immunodeficiency virus type 1 disease progression in hemophiliacs. J. Infect. Dis. 183: 589-595, 2001.
  424. Kim, J.-H., Eizirik, E., O’Brien, S.J., and Johnson, W. E.: Structure and evolution of the mitochondrial DNA control region in the great cats (Panthera). Mitochondrion.1:279-292, 2001.
  425. Eizirik, E., Kim, J.-H., Menotti-Raymond, M., Crawshaw, P. G. Jr., O’Brien, S.J., and Johnson, W. E.: Phylogeography, population history and conservation genetics of jaguars (Panthera onca, Mammalia, Felidae). Mol. Ecol.10:65-79, 2001.
  426. Sun, S., Murphy, W. J., Menotti-Raymond, M., and O’Brien, S.J.: Integration of the feline radiation hybrid and linkage maps. Mammalian Genome 12: 436-441, 2001.
  427. Lu, Z., Johnson, W. E., Menotti-Raymond, M., Yuhki, N., Martenson, J., Mainka, S., Shi-qiang, H., Zhihe, Z., Li, G., Pan, W., and O’Brien, S.J.: Patterns of genetic diversity in remaining giant panda populations. Conservation Biol. 15: 1596-1607, 2001.
  428. Menotti-Raymond, M., David, V., Wachter, L., Yuhki, N. and O’Brien, S.J.: Quantitative polymerase chain reaction-based assay for estimating DNA yield extracted from domestic cat specimens. Croat. Med. J. 44: 327-331, 2003.
  429. Chomel, B.B., Kikuchi, Y., Martenson, J.S., Roelke-Parker, M.E., Chang, C.C., Kasten, R.W., Foley, J.E. Laudre, J., Murphy, K., Swift, P.K., Kramer, V.L., and O’Brien, S.J.: Seroprevalence of Bartonella infection in American free-ranging and captive pumas (Felis concolor) and bobcats (Lynx rufus). Vet Res. 35:233-241, 2004.
  430. O’Brien, S.J.: Human genetic factors that impact HIV infection and progression. Clinical Care Options for HIV Symposium. In Phair, J. P. and King, E. (Eds.): Medscape HIV/AIDS Annual Update 2000. New York, Medscape, pp. 19-28, 2000.
  431. O’Brien, S.J. and Moore, J.: The effect of genetic variation in chemokines and their receptors on HIV transmission and progression to AIDS. Immunol. Rev. 177: 99-111, 2000.
  432. O’Brien, S.J.: The Cat Family. In D. Macdonald, (ed.), Encyclopedia of Mammals. Oxford, Oxford University Press, 2001, pp. 8-9.
  433. Yamashita, T. E., Phair, J. P., Munoz, A., Margolick, J. B., Detels, R., O’Brien, S.J., Mellors, J. W., Wolinsky, S., and Jacobson, L. P.: Immunologic and virologic response to highly active antiretroviral therapy in the Multicenter AIDS Cohort Study. AIDS 15:735-746, 2001.
  434. Sarno, R.J., L. Villalba, C. Bonacic, B. Gonzalez, B. Zapata, D.W. MacDonald, S.J. O’Brien, and W. E. Johnson. Phylogeography and subspecies assessment of vicuñas in Chile and Bolivia utilizing mtDNA and microsatellite markers: implications for vicuña conservation and management. Conservation Genet. 5:89-102, 2004.
  435. Modi, W.S., Goedert, J.J., Strathdee, S., Buchbinder, S., Detels, R., Donfield, S., O’Brien, S.J. and Winkler, C.: MCP-1-MCP-3-Eotaxin gene cluster influences HIV-1 transmission AIDS 17:2357-2365, 2003.
  436. Uphyrkina, O., Johnson, W., Quigley, H., Miquelle, D., Marker, L., Bush, M., and O’Brien, S.J.: Phylogenetics, genome diversity and the origin of modern leopard, Panthera pardus. Mol. Ecol. 10:2617-2633, 2001.
  437. Smith MW, Lautenberger JA, Shin HD, Chretien JP, Shrestha S, Gilbert DA, O’Brien SJ. Markers for mapping by admixture linkage disequilibrium in African American and Hispanic populations. Am J Hum Genet. 2001 Nov;69(5):1080-94.
  438. Gao, X., Nelson, G. W., Karacki, P., Martin, M. P., Phair, J., Kaslow, R., Goedert, J. J., Buchbinder, S., Koots, K., Vlahov, D., O’Brien, S.J., and Carrington, M.: Effect of a single amino acid change in MHC class I molecules on the rate of progression to AIDS. New Engl J Med 344:1668-1675, 2001.
  439. Roelke-Parker, M. E, Slattery, J.P., VandeWoude, S., and O’Brien, S.J. T-lymphocyte profiles in FIV infected wild lions and pumas reveal CD4 depletion. J Wildlife Dis.42: 234-248, 2006.
  440. O’Brien, S.J., Nelson, G. W., Winkler, C. A., and Smith, M. W.: Polygenic and multifactorial disease gene association in man: Lessons from AIDS. Ann Rev Genet 34: 563-591, 2000.
  441. Beck, T. W., Menninger, J., Voight, G., Newmann, K., Nishigaki, Y., Nash, W. G., Stephens, R. M., Wang, Y., de Jong, P. J., O’Brien, S.J., and Yuhki, N.: Comparative feline genomics: BAC/PAC contig map of the major histocompatibility complex class II region. Genomics 71:282-295, 2001.
  442. Comstock, K. E., Georgiadis, N., Pecon-Slattery, J., Roca, A. L., Ostrander, E. A., O’Brien, S.J., and Wasser, S. K.: Patterns of molecular genetic variation among African elephant populations. Mol. Ecol. 11: 2489-2498, 2002.
  443. Roca, A. L., Georgiadis, N., Pecon-Slattery, J., and O’Brien, S.J.: Genetic evidence for two species of elephant in Africa. Science 293: 1473-1477, 2001.
  444. Sarno, R. J., David, V. A., Franklin, W. L., O’Brien, S.J., and Johnson, W. E.: Development of microsatellite markers in the guanaco, Lama guanicoe: Utility for South American camelids. Mol. Ecol. 9: 1922-1924, 2000.
  445. Vande Woude, S., Hageman, C. A., O’Brien, S.J., and Hoover, E. A.: Nonpathogenic lion and puma lentiviruses impart resistance to superinfection by virulent feline immunodeficiency virus. J. Acquir Immune Defic Syndr 29:1-10, 2002.
  446. Roca, A., Slattery, J.P., and O’Brien, S.J.: Genomically intact endogenous feline leukemia viruses of recent origin. J Virol. 78: 4370-4375, 2004.
  447. O’Brien, S.J.: Cell culture forensics. Proc. Natl. Acad. Sci. USA 98: 7656-7658, 2001.
  448. Parker, J. S. L., Murphy, W. J., Wang, D., O’Brien, S.J., and Parrish, C. R.: Canine and feline parvoviruses can use the human or feline transferrin receptors to bind, enter and infect cells. J. Virol. 75: 3896-3902, 2001.
  449. Johnson, W.E., Eizirik, E., Roelke-Parker, M., O’Brien, S.J.: Applications of genetic concepts and molecular methods to carnivore conservation. In: Carnivore Conservation (J. Gittleman, S. Funk, P. Macdonald, and R. Wayne, eds), Cambridge University Press Pp. 335-358, 2001.
  450. Murphy, W. J., Eizirik, E., Johnson, W. E., Zhang, Y. P., Ryder, O. A., and O’Brien, S.J.: Molecular phylogenetics and the origins of placental mammals. Nature. 409: 614-618, 2001.
  451. Eizirik, E., Murphy, W. J., and O’Brien, S.J.: Molecular dating and biogeography of the early placental mammal radiation. J. Hered. 92: 212-219, 2001.
  452. An, P., Nelson, G. W., Wang, L., Donfield, S., Goedert, J. J., Phair, J., Vlahov, D., Buchbinder, S., Farrar, W. L., Modi, W., O’Brien, S.J. and Winkler, C. A.: Modulating influence on HIV/AIDS by interacting RANTES gene variants. Proc Natl Acad Sci USA 99:10002-10007, 2002
  453. Carrington, M., Nelson, G., and O’Brien, S.J.: Review and Commentary: Considering genetic profiles in functional studies of immune responsiveness to HIV-1. Immunol Lett 79:131-140, 2001.
  454. Thio, C. L., Thomas, D. L., Goedert, J. J., Vlahov, D., Nelson, K. E., Hilgartner, M. W., O’Brien, S.J., Karacki, P., Marti, D., Astemborski, J., and Carrington, M.: Racial differences in HLA-Class II associations with hepatitis C virus outcomes. J. Infect. Dis. 184: 16-21, 2001.
  455. Nash, W. G., Menninger, J. C., Wienberg, J., Padilla-Nash, H. M., O’Brien, S.J.: The pattern of phylogenomic evolution of the Canidae. Cytogenet. Cell Genet. 95: 210-224, 2001.
  456. O’Brien, S.J., Eizirik, E., and Murphy, W. J.: Genomics. On choosing mammalian genomes for sequencing. Science. 292: 2264-2266, 2001.
  457. Yang, O.O., Boscardin, W.J, Matud, J., Hausner, M.A., Hultin, L.E., Hultin, P.M., Shih, R., Ferbas, J., Siegal, F.P., Shodell, M., Shearer, G.M., Grene, E., Carrington, M., O’Brien, S., Price, C.B., Detels, R., Jamieson, B.D., Giorgi, J.V.: Immunologic profile of highly exposed yet HIV type 1-seronegative men. AIDS Res Hum Retroviruses. 18:1051-1065, 2002.
  458. Uphyrkina, O., Miquelle, D., Quigley, H., Driscoll, C., and O’Brien, S.J.: Conservation genetics of the far eastern leopard (P. p. orientalis). J. Hered. 93:303-311, 2002.
  459. Johnson, W., O’Brien, S.J., and Culver, M.: Small Cats. In D. Macdonald, ed., Encyclopedia of Mammals. Oxford, Oxford University Press, 2001, pp. 32-34.
  460. Dean, M., Carrington, M., O’Brien, S.J.: Balanced polymorphism selected by genetic versus infectious human disease. Ann. Rev. Genomics Hum Genet 3:263-292, 2002.
  461. Menotti-Raymond, M., David, V. A., Chen, Z.-Q., Menotti, K., Sun, S., Schaffer, A. A., Agarwala, R., Tomlin, J. F., O’Brien, S.J. and Murphy, W. J.: Second-generation integrated genetic linkage/radiation hybrid maps of the domestic cat (Felis catus). J. Hered. 94: 95-106, 2003.
  462. Yamaguchi, N., Sarno, R. J., Johnson, W. E., O’Brien, S.J., and Macdonald, D. W.: Multiple paternity and reproductive tactics of free-ranging American mink, Mustela vison. J. Mammal. 85: 432-439, 2004.
  463. Palomares, F., Godoy, J. A., Piriz, A., O’Brien, S.J., and Johnson, W. E.: Faecal genetic analysis to determine presence and distribution of elusive carnivores: Design and feasibility for the Iberian lynx. Mol. Ecol. 11: 2171-2182, 2002.
  464. Breen, E.C., Boscardin, W.J., Detels, R., Jacobson, L.P., Smith, M.W., O’Brien, S.J., Chmiel, J. S., Rinaldo, C.R., Lai, S., and Martínez-Maza, O. Non-Hodgkin’s B cell – lymphoma in persons with acquired immunodeficiency syndrome is associated with increased serum levels of IL10, or the IL10 promoter –592 C/C genotype. Clin. Immunol. 109: 119-129, 2003.
  465. Murphy, W. J., Eizirik, E., O’Brien, S.J., Madsen, O., Scally, M., Douady, C., Teeling, E., Ryder, O.A., Stanhope, M., de Jong, W. W., and Springer, M. S.: Resolution of the early placental mammal radiation using Bayesian phylogenetics. Science 294: 2348-2351, 2001.
  466. Duggal, P., An, P., Beaty, T., Strathdee, S. A., Farzadegan, H., Markham, R. B., Johnson, L., O’Brien, S.J., Vlahov, D., and Winkler, C. A.: Genetic influence of CXCR6 chemokine receptor alleles on PCP-mediated AIDS progression among African-Americans. Genes Immun. 4: 245-250, 2003.
  467. O’Brien, S.J., Gao, X., and Carrington, M.: HLA and AIDS: A cautionary tale. Trends Mol. Med. 7: 379-381, 2001.
  468. Yuhki, N., Beck, T., Stephens, R. M., Nishigaki, Y., Newmann, K., and O’Brien, S.J.: Comparative genome organization of human, murine and feline MHC class II region. Genome Res. 13: 1169-1179, 2003.
  469. Eizirik, E., Yuhki, N., Johnson, W., Menotti-Raymond, M., Hannah, S. S. and O’Brien, S.J. Molecular genetics and evolution of melanism in the cat family (Mamalia Felidae.). Cur Biol. 13: 448-453, 2003
  470. Carrington, M., Gao, X., O’Brien, S.J.: HLA and AIDS progression. Letter to Editor, New England Journal of Medicine 345:924-925, 2001.
  471. Martin, M.P., Gao, X., Lee, H. -L, Nelson, G., Detels, R., Goedert, J.J., Buchbinder, S., Hoots, K., Vlahov, D., Trowsdale, J., Wilson, M., O’Brien, S.J. and Carrington, M.: Epistatic interaction between KIR3DS1 and HLA-B delays the progression to AIDS. Nature Genet. 31: 429-434, 2002.
  472. An, P., Vlahov, D., Margolick, J.B., Phair, J., O’Brien, T.R., Lautenberger, J., O’Brien, S.J. and Winkler, C.A.: A tumor necrosis factor-alpha-inducible promoter variant of interferon-gamma accelerates CD4+ T cell depletion in human immunodeficiency virus-1-infected individuals. J Infect Dis.188:228-231, 2003.
  473. Johnson, W.E., Godoy, J.A., Palomares, F., Delibes, M., Fernandes, M., Revilla, E., O’Brien, S.J.: Phylogenetic and phylogeographic analysis of Iberian lynx population. J. Hered. 95:19-28, 2004.
  474. O’Brien, S.J.: Feline Genetics. Encyclopedia of Genetics. Academic Press.pp 684-685, 2001
  475. Liu, C., Carrington, M., Kaslow, R., Rinaldo, C., Jacobson, L., Margolick, J., Phair, J., O’Brien, S.J., Detels, R.: Association of polymorphisms in HLA Class I and TAP genes with resistance to HIV-1 infection. J Infect Dis 187: 1404-1410, 2003.
  476. O’Brien, S.J., Menotti-Raymond, M., Murphy, W.J., Yuhki, N. The Feline Genome Project. Ann Rev Genetics 36:657-686, 2002.
  477. Copeland, N., Jenkins, N., O’Brien, S.J. Mmu 16- Comparative Genomic Highlights. Science 296: 1617-1618, 2002.
  478. Beck, T., Menninger, J., Murphy, W.J., Nash, W.G., Yuhki, N., and O’Brien, S.J.: The feline major histocompatibility complex is rearranged by an inversion with a breakpoint in the distal class I region. Immunogenetics 56:702-709, 2005.
  479. Murphy, W.J., Page, J.E., Smith, C. Jr., Desrosiers, R.C., and O’Brien, S.J.: A radiation hybrid mapping panel for the Rhesus macacque. J. Hered. 92: 516-519, 2001.
  480. Springer, M.S., Murphy, W. J. Eizirik, E., O’Brien, S.J.: Placental mammal diversification and the Cretaceous-Tertiary boundary. Proc. Nat. Acad. Sci. USA 100:1056-1061, 2003.
  481. David, V.A., Sun, S., Fujun, S, Zhihe, Z, Zhang, Y-P, Guiquan, Z, Hemin, Z, Zhong, X, Ellis, S. Wildt, D. S.J. O’Brien: Paternity analysis in captive bred giant pandas. In: Giant Pandas: Biology, Veterinary and Management and Medicine, (Wildt, D.E., Zhang, A., Zhang, H., and Janssen, D.L. and Ellis, S. Eds.), Cambridge University Press, England pp 245-273, 2003.
  482. Eizirik, E., Murphy, W.J., Springer, M.S., O’Brien, S.J. Molecular phylogeny and dating of early primate divergences. In: Anthropoid Origins, New Visions. Ross, C.F. and Kay, R.F. Eds., Kluwer/Plenum. pp 45-64, 2004.
  483. Lento, G.M., Baker, C.S., David, V., Yuhki, N., Gales, N.J., O’Brien, S.J.: Automated single-strand conformation polymorphism reveals low diversity of a Major Histocompatibility Complex Class II gene in the threatened New Zealand sea lion. Molec. Ecol. 3: 346-349, 2003.
  484. Carrington, M., O’Brien, S.J. The Influence of HLA Genotype on AIDS. Ann. Rev. Med. 54: 535-551, 2003.
  485. Uphyrkina, O. and O’Brien, S.J.: Applying molecular genetic tools to the conservation and action plan for the critically endangered Far Eastern leopard (Panthera pardus orientalis). C.R. Biologies 326:S93-S97, 2003.
  486. Jin, X., Gao, X., Ramanathan, M., Deschenes, G.R., Nelson, G., O’Brien, S.J., Goedert, J. J., Ho, D. D., O’Brien, T. R., Carrington, M.: Human immunodeficiency virus Type 1 (HIV-1)-specific CD8+-T-cell responses for groups of HIV-1-infected individuals with different HLA-B*35 genotypeS.J. Virol. 76: 12603-12610, 2002.
  487. Butler, J. M., David, V. A., O’Brien, S.J., and Menotti-Raymond, M.: The “MeowPlex”: A new DNA test using tetranucleotide STR markers for the domestic cat. Profiles in DNA 5:7-10, 2002.
  488. Modi, W.S., O’Brien, T.R., Vlahov, D., Buchbinder, S., Gomperts, E., Phair, J., and O’Brien, S.J. and Winkler, C.: Haplotype diversity in the Interleukin-4 gene is not associated with HIV-1 transmission and AIDS progression. Immunogenet 55:157-164, 2003.
  489. Kikuchi, Y., Chomel, B.B., Kasten, R.W., Martenson, J.S., Swift, P.K., and O’Brien, S.J.: Seroprevalence of Toxoplasma gondii in American free-ranging or captive pumas (Felis concolor) and bobcats (Lynx rufus). Vet Parasitol 120:1-9, 2004.
  490. Pecon-Slattery, J., Pearks-Wilkerson, A.J., Murphy, W.J., and O’Brien, S.J.: Phylogenetic assessment of introns and SINEs within the Y-chromosome using the cat family Felidae as a species tree. Mol Biol Evol 21:2299-2309, 2004.
  491. Murphy, W.J., Frönicke, L., O’Brien, S.J. and Stanyon, R.: The origin of human chromosome 1 and its homologs in placental mammals. Genome Res. 13: 1880-1888, 2003.
  492. House, C., Alexander, K.A., Kat, P.W., O’Brien, S.J., Mangiafico, J.: Serum antibody to Rift Valley fever virus in African carnivores. Ann N Y Acad Sci. 1996 Jul 23;791:345-9.
  493. Luo, S.-J., Kim, J.-H., Johnson, W.E., van der Walt, J., Martenson, J., Yuhki, N., Miquelle, D.G., Uphyrkina, O., Goodrich, J.M., Quigley, H.B., Tilson, R., Brady, G., Martelli, P., Subramaniam, V., McDougal, C., Hean, S., Huang, S.-Q., Pan, W., Karanth, U.K., Sunquist, M., Smith, J.L.D., and O’Brien, S.J.:Phylogeography and genetic ancestory of tigers (Panthera tigris). PLoS Biology 2:2277-2293, 2004.
  494. Troyer, J.L., Pecon-Slattery, J., Roelke Parker, M.E., Black, L., Packer, C., and O’Brien, S.J.: Patterns of feline immunodeficiency virus multiple infection and genome divergence in a free-ranging population of African lions. J Virol.78: 3777-3791, 2004.
  495. Nelson, G.W. and O’Brien, S.J.: Using mutual information to measure the impact of multiple genetic factors on AIDS. J Acquir Immune Defic Syndr 42: 347-354, 2006.
  496. Thio, C.L., Mosbruger, T.L., Kaslow, R.A., Karp, C.L., Strathdee, S.A., Vlahov, D., O’Brien, S.J., Astemborski, J., and Thomas, D.L.: Cytotoxic T-lymphocyte antigen 4 gene and recovery from hepatitis B virus infection. J Virol 78:11258-11262, 2004
  497. Kuznetsov, S., Matveeva, N.M., Murphy, W.J., O’Brien, S.J. and Serov, O.L.: Mapping of 53 loci in American mink (Mustela vison). J. Hered. 94:386-391, 2003.
  498. Teeling, E.C., Madsen, O., Murphy, W.J., Springer, M.S., and O’Brien, S.J.: Nuclear gene sequences confirm an ancient link between New Zealand’s short-tailed bat and South American noctilionoid bats. Molec. Phylogenet. Evol. 28: 308-319, 2003.
  499. Swanson, W.F., Johnson, W.E., Cambre, R.C., Citino, S.B., Quigley, K.B., Brousset, D.M., Morais, R.N., Moreira, N., O’Brien, S.J. and Wildt, D.E.: Reproductive status of endemic felid species in Latin American zoos and implications for ex situ conservation. Zoo Biol. 0:1-21, 2003.
  500. O’Brien, S.J. and Nelson, G.W.: Human genes that limit AIDS. Nature Genetics.36:565-574, 2004.
  501. Daar, E. S., Lynn, H., Donfield, S., Lail, A., O’Brien, S.J., Huang, W., and Winkler, C.: Stromal cell-derived factor-1 genotype, coreptor tropism, and HIV type 1 disease progression. Journal of Infectious Diseases 192:1597-1605, 2005.
  502. Silverberg M.J., Smith, M.W. Chmiel, J.S., Detels, R., Margolick, J.B., Rinaldo, C.R., O’Brien, S.J., and Muñoz, A.: Fraction of cases of acquired immunodeficiency syndrome prevented by the interactions of identified restriction gene variants. Am J Epidemiol. 159: 232-241, 2004.
  503. Murphy, W.J., Bourque, G., Tesler, G., Pevzner, P. and O’Brien, S.J.: Reconstructing the genomic architecture of mammalian ancestors using multispecies comparative maps. Hum. Genomics. 1: 30-40, 2003.
  504. Roca, A.L., Georgiadis, N. and O’Brien, S.J.: African elephant genetics: request for samples. Pachyderm. 33:93-95, 2002.
  505. He Q., Lowrie, C., Shelton, G.D., Castellani, R.J., Menotti-Raymond, M., Murphy, W., O’Brien, S.J., Swanson, W.F., Fyfe, J.C.: Inherited motor neuron disease in domestic cats: a model of spinal muscular atrophy. Pediatr Res. 57:324-30, 2005.
  506. Thio, C.L, Thomas, D.L., Karacki, P., Gao, X., Marti, D., Kaslow, R.A., Goedert, J.J., Hilgartner, M, Strathdee, S., Duggal, P., O’Brien, S.J., Astemborski, J., and Carrington, M.: Comprehensive Analysis of Class I and Class II HLA Antigens and Chronic Hepatitis B Virus Infection. J Virol. 77:12083-12087, 2003.
  507. Baker, C.S., Vant, M.D., Dalebout, M.L., Lento, G.M., O’Brien, S.J., Yuhki, N.: Diversity and duplication of DQB and DRB-like genes of the MHC in baleen whales (suborder: Mysticeti) Immunogenetics 58:283-296. 2006.
  508. Roca, A.L., Georgiadis, N. and O’Brien, S.J.: Cytonuclear genomic dissociation in African elephant species. Nature Genetics.37:96-100, 2005.
  509. Marker, L.L., Wilkerson, A.J., Sarno, R.J., Martenson, J., Breitenmoser-Wursten, C., O’Brien, S.J., and Johnson, W.E.: Molecular genetic insights on cheetah (Acinonyx jubatus) ecology and conservation in Namibia. J Hered 99: 2-13, 2008.
  510. Thio, C.L., Gao, X., Goedert, J.J., Vlahov, D., Nelson, K.E., Hilgartner, M.W., O’Brien, S.J., Karacki, P., Astemborski, J., Carrington, M., and Thomas, D.L.: HLA-Cw*04 and Hepatitis C virus persistence. J. Virol. 76:4792-4797, 2002.
  511. O’Brien, S.J. and Fraser, C.M.: Genomes and evolution. The power of comparative genomics. Curr Opin Genet Dev 15:569-571, 2005.
  512. Owl monkey cell line. Science. 1981 Jun 12; 212:1214.
  513. Dean M, Carrington M, Goedert J, O’Brien SJ. Participants in HIV Study: .Science. 1996 Nov 15;274(5290):1069
  514. Oleksyk, T.K., Goldfarb, L.G., Sivtseva, T., Danilova, A.P., Osakovsky, V.L., Shrestha, S., O’Brien, S.J., and Smith, M.W.: Evaluating association and transmission of eight inflammatory genes with Viliuisk encephalomyelitis susceptibility. Eur J Immunogenet, 31:121-128, 2004
  515. Menotti-Raymond, M.A., David, V.A., Wachter, L.A., Butler, J.M., and O’Brien, S.J.: An STR forensic typing system for genetic individualization of domestic cat (Felis catus) Samples. J Forensic Sciences 50:1061-1070, 2005.
  516. Thio, C. L., S. J. O’Brien, et al. (2002). “The importance of assessing effect modification when asserting racial differences in associations between human leukocyte antigen class II alleles and hepatitis C virus outcomes – Reply.” Journal of Infectious Diseases 185(2): 267-268
  517. Roca, A.L., Nash, W.G., Menninger, J.C., Murphy, W.J., and O’Brien, S.J.: Insertional Polymorphisms of Endogenous Feline Leukemia ViruseS.J. Virol. 79: 3979-3986. 2005.
  518. Duggal, P., Winkler, C.A., An, P., Farzadegan, H., O’Brien, S.J., Beaty, T.H. and Vlahov, D.: The effect of RANTES chemokine genetic variations on initial HIV-1 plasma RNA among seroincident injection drug users (IUDs). JAIDS 38:584-589. 2005.
  519. O’Brien, S.J. and Nelson, G.: AIDS restriction genes – a review. Russian Journal of AIDS, Cancer and Public Health 10: 42-57, YEAR
  520. Dawson, L., Bateman-House, A.S. Mueller-Agnew, D., Bok, H., Brock, D.W., Chakravarti, A., Greene, M., King, P.A., O’Brien, S.J., Sachs, D.H., Schill, K.E., Siegel, A., Solter, D., Suter, S.M., Verfaillie, C.M., Walters, L.B., Gearhart, J.D., Faden, R.R.: Safety issues in cell-based intervention trials. Fertil. Steril. 80: 1077-1085. 2003. Erratum in: Fertil Steril. 81:226, 2004.
  521. Pearks-Wilkerson, A.J., Teeling, E.C., Troyer, J.L., Bar-Gal, G.K., Roelke, M., Marker, L., Pecon-Slattery, J., O’Brien, S.J.: Coronavirus outbreak in cheetahs: Lessons for SARS. Curr Biol. 14: R227-R228. 2004.
  522. O’Brien S.J and W J Murphy: A dog’s breakfast? Science 301:1854-1855. 2003
  523. Karacki, P.S., Gao Xiaojiang, Thio, C.L., Thomas, D.L., Goedert, J.J., Vlahov, D., Kaslow, R.A., Strathdee, S., Hilgartner, M.W., O’Brien, S.J., and Carrington, M: MICA and recovery from hepatitis C virus and hepatitis B virus infections. Genes Immun. 5:261-266, 2004.
  524. Eizirik, E. and O’Brien, S.J.: Evolution of melanism in the felidae. Cat News 38:37-39. 2003.
  525. Faden R.R., Dawson, L., Bateman-House, A.S., Agnew, M.D., Bok, H., Brock, D.W., Chakravarti, A., Gao, X-J., Greene, M., Hansen. J.A., King, P.A., O’Brien, S.J., Sachs, D.H., Schill, K.E., Siegel, A., Solter, D. Suter, S.M. Verfaillie, C.M., Walters, L.B. and Gearhart, J.D.: Public stem cell banks: considerations of justice in stem cell research and therapy. Hastings Cent Rep 33:13-27, 2003.
  526. Ballou, J.D., Miller, P.S., Zhong, X., Rongping, W., Hemin, Z., Anju, Z., Shiqiang, H., Shan, S., David, V., O’Brien, S.J., Seal, U.S., and Wildt. D.: Analyses of demographic and genetic trends for developing a captive breeding master plan for giant pandas. In: Giant Pandas: Biology, Veterinary and Management and Medicine, (Wildt, D.E., Zhang, A., Zhang, H., and Janssen, D.L. and Ellis, S. Eds.), Cambridge University Press, England, 2003.
  527. Johnson, W.E., Eizirik, E., O’Brien, S.J.: Evolución y Genética de poblaciones de jaguar: implicaciones para los esfuerzos futuros de conservación. The Jaguar Book. Pp. 519-534. 2003.
  528. Liu, C., Carrington, M, Kaslow, R.A. Gao, X., Rinaldo, C.R., Jacobson, L.P., Margolick, J.B., Phair, J., O’Brien, S.J., and Detels, R.: Lack of association between HLA Class II alleles and resistance to HIV-1 infection among white, non-Hispanic homosexual men. J Acquir Immune Defic Syndr. 37:1313-1317, 2004.
  529. Menotti-Raymond, M., David, V.A., Agarwala, R., Schäffer, Stephens, R., O’Brien, S.J., Murphy, W.J.: Radiation hybrid mapping of 304 novel microsatellites in the domestic cat genome. Cytogenet Genome Res.:102: 272-276, 2003.
  530. Winkler, C.A., Hendel, H., Carrington, M., Smith, M.W., Nelson, G.W., O’Brien, S.J., Phair, J., Vlahov, D., Rappaport, J., Haumont, P., Bertin-Maghit, S., Lu, W., Andrieu, J.-M., Schächter, F., Therwath, A. and Zagury, J.-F.: Early dominant effects of CCR2-CCR5 haplotypes in HIV-1 disease progression. J AIDS 37:1534-1538, 2004.
  531. Springer, M. S., Murphy, W. J., Eizirik, E., and S.J. O’Brien. A molecular view on relationships among the extant orders of placental mammals. In: Molecular evidence for the rise of Placental Mammals, major placental clades (K.D. Rose & J.D. Archibald, eds.) The Johns Hopkins University Press, Baltimore, MD. 2004.
  532. Roca, A.L., Kahila Bar-Gal, G., Eizirik, E., Helgen, K.M., Maria, R., Springer, M.S., O’Brien, S.J. and Murphy, W.J.: Mesozoic origin for West Indian insectivores. Nature 429:649-651. 2004.
  533. Zhang, Zhi-He, Shen, Fu-Gun, Sun Shan, David, V.A., Zhang, An-Ju, O’Brien, S.J.: Paternity assignment of giant panda by microsatellite genotyping. Hereditas (Beijing) 25: 404-510. 2003.
  534. Martin, M.P., Lederman, M., Hutcheson, H., Nelson, G.W. Goedert, J.J., Detels, R., Buchbinder, S., Hoots, K., Vlahov, D., O’Brien, S.J. and Carrington, M.: Association of DC SIGN promoter polymorphisms with increased risk for parenteral but not mucosal acquisition of HIV-1 infection. J Virol 78:14053-14056. 2004.
  535. Winkler, C., An, P., and O’Brien, S.J.: Patterns of ethnic diversity among the genes that influence AIDS. Hum Mol Genet. 13: R9-R19. 2004.
  536. Guo, X.C., O’Brien, S.J., Zeng, Y.: Impact of host genetic polymorphism on HIV/AIDS infection and progression. Chin Sci Bulletin 51:2705-2713, 2006.
  537. Troyer, J., Pecon-Slattery, J. Roelke-Parker, M., Johnson, W., VandeWoude, S., Vazquez-Salat, Nuria, Brown, M., Frank, L., Woodroffe, R., Winterbach, C., Winterbach, H., Hemson, G., Bush, M., Alexander, K.A., Revilla, E., and O’Brien, S.J.: Seroprevalence and genomic diversity of circulating strains of feline immunodeficiency virus among Felidae and Hyaenidae species. J Virol. 79:8282-8294. 2005.
  538. Smith, M.W., Patterson, N.J., Lautenberger, J.A., Truelove, A.L., McDonald, G.J., Waliszewska, A., Kessing, B.D., Kessing, B.D., Malasky, M.J., Scafe, C., Le, E., De Jager, P.L., Mignault, A.A., Yi, Z., de The, G., Essex, M., Sankale, J.-L., Moore, J.H., Poku, K., Phair, J.P., Goedert, J.J., Vlahov, Williams, S.M., Tishkoff, S.A., Winkler, C.A., De La Vega, F.M., Woodage, T., Sninsky, J.J., Hafler, D.A., Altshuler, D., Gilbert, D.A., O’Brien, S.J. and Reich, D.E.: A high density admixture map for disease gene discovery in African Americans. Am. J. Hum. Genet. 74: 1001-1013, 2004.
  539. Patterson, N., Hattangadi, N., Lane, B., Lohmueller, K.E., Hafler, D.A., Oksenberg, J.R., Hauser, S.L., Smith, M., O’Brien, S.J., Altshuler, D., Daly, M., and Reich, D.: Methods for high density admixture mapping of disease genes. Am. J. Hum. Gen. 74: 979-1000, 2004.
  540. An, P. Bleiber, G., Duggal, P., Nelson, G., May, M., Mangeat, B., Alobwede, I., Trono, D., Vlahov, D., Donfield, S., Goedert, J.J., Phair, J., Buchbinder, S., O’Brien, S.J., Telenti, A., and Winkler, C.A.: APOBEC3G genetic variants and their influence on the progression to AIDS. J Virol 78:11070-11076, 2004.
  541. De La Vega, F.M., Isaac, H., Collins, A., Scafe, C.R., Halldórsson, B.V., Su, X., Lippert, R.A., Wang, Y., Laig-Webster, M., Koehler, R.T., Ziegle, J.S., Wogan, L.T., Stevens, J.F., Leinen, K.M., Olson, S.J., Guegler, K.J., You, X., Xu, L.H., Hemken, H.G., Kalush, F., Itakura, M., O’Brien, S.J., Clark, A.G., Istrail, S., Hunkapiller, M.W., Spier, E.G., and Gilbert, D.A.: The linkage disequilibrium maps of three human chromosomes across four populations reflect their demographic history and a common underlying recombination pattern. Genome Res 15:454-462, 2005.
  542. Khakoo, S.I., Thio, C.L., Martin, M.P., Brooks, C.R., Gao, X., Astemborski, J., Goedert, J.J., Vlahov, D., Hilgarten, M., Cox, S., Little, A.-M., Alexander, G.J. Cramp, M.E., O’Brien, S.J., Rosenberg, W.M.C., Thomas, D.L., and Carrington, M.: HLA and NK cell inhibitory receptor genes in resolving hepatitis C virus infection. Science 305:872-874, 2004.
  543. Gao, X., Bashirova, A., Iversen, A.K.N., Phair, J., Goedert, J.J., Buchbinder, S., Hoots, K., Vlahov, D., Altfeld, M., O’Brien, S.J., and Carrington, M.: AIDS restriction HLA allotypes target distinct intervals of HIV-1 pathogenesis. Nat Med. 11: 1290-1292, 2006.
  544. O’Brien SJ. Comparative genomics in vertebrates: a role for the platypus.Reprod Fertil Dev. 2009;21(8):vii-ix.
  545. Johnson, W.E., Eizirik, E., Murphy, W.J., Pecon-Slattery, J., Antunes, A., Teeling, E. and O’Brien, S.J.: The late Miocene radiation of modern felidae: A genetic assessment. Science.311:73-77. 2006.
  546. King, V., Goodfellow, P., Pearks-Wilkerson, A.J., O’Brien, S.J., Pecon-Slattery, J.: Evolution of the male determining gene SRY and adjacent genomic flanks within the cat family Fedidae. Genetics 175: 1855-1867, 2007.
  547. Kim, J.-H., Antunes, A., Luo, S., Menninger, J., Nash, W.G., O’Brien, S.J., Johnson, W.E.: Evolutionary analysis of a large mtDNA translocation (numt) into the nuclear genome of the Panthera genus fields. Gene 366: 292-302, 2006.
  548. O’Brien, S.J., Eisenberg, J.F., Miyamoto, M., Hedges, S.B., Kumar, S., Wilson, D.E. Minotti-Raymond, M., Murphy, W.J., Nash, W.G., Lyons, L.A., Menninger, J.C., Stanyon, R., Wienberg, J., Copeland, N.G., Jenkins, N.A., Gellin, J., Yerle, J., Andersson, L., Womack, J., Broad, T., Postlethwait, J., Serov, O., Bailey E., James, M.R., Marshal Graves, J.A., et al. Genone Maps 10. Comparative genomics. Mammalian radiations. Wall chart. Science 286:463-478,1999.
  549. Murphy, W.J. Pevzner, P., O’Brien, S.J.: Mammalian phylogenetics comes of age. Trends Genet 20:631-639, 2004.
  550. Thio, C.L., Goedert, J.J., Mosbruger, T., Vlahov, D., Strathdee, S.A., O’Brien, S.J., Astemborski, J., Thomas, D.L.: An analysis of tumor necrosis factor alpha gene polymorphisms and haplotypes with natural clearance of hepatitis C virus infection. Genes Immun.5:294-300, 2004.
  551. Vila, C., Leonard, J.A., Iriarte, A., O’Brien, S.J., Johnson, W.E., and Wayne, R.K.: Detecting the vanishing populations of the highly endangered Darwin’s fox, Pseudalopex fulvipes. Animal Conservation 7:147-153, 2004.
  552. Jones, J.W., Culver, M., David, V., Struthers, J., Johnson, N., Neves, R.J., O’ Brien, S.J., and Hallerman, E.M.: Development and Characterization of Microsatellite Loci in the Endangered Oyster Mussel Epioblasma capsaeformis (Bivalvia:Unionidae) Molecular Ecology Notes, 10.1111/j.1471-8286, 2004.
  553. Guo, X.-C., Scott, K.,Yan, L., Dean, M., David, V., Nelson, G., Johnson, r., Dilks-Hutcheson, H., Lautenberger, J., Kessing, B., Martenson, J., Li, G., Shan, S., Hong, D., Yuming, Z., de The, G., Jian L., Zeng, Y., O’Brien, S.J, Winklker, C. A..: Genetic factors leading to chronic Epstein-Barr virus infection and nasopharyngeal carcinoma in South East China: Study design, methods and feasibility. Human Genomics 2: 365-375, 2006.
  554. Thio, C.L., Mosbruger, T., Astemborski, J., Greer, S., Vlahov, D., O’Brien, S.J., and Thomas, D.L.: Mannose binding lectin genotypes influence recovery from hepatitis B virus infection. J Virol 79:9192-9196, 2005.
  555. O’Brien, S.J.: Male Musings Book Review of “Adam’s Curse: A future without men” by Bryan Sykes. W. W. Norton & Company, New York, 2004. http://www.genomenewsnetwork.org/articles/2004/09/03/adams_curse.php
  556. Oleksyk, T.K., Thio, C.L. Truelove, A.L., Goedert, J.J., Donfield, S.M., Kirk, G.D., Thomas, D.L., O’Brien, S.J. and Smith, M.W.: Single nucleotide polymorphisms and haplotypes in the IL10 region associated with HCV clearance. Genes and Immunity 6:347-357, 2005.
  557. Teeling, E., Springer, M.S., Madsen, O., Bates, P., O’Brien, S.J., and Murphy, W.J.: A molecular phylogeny for bats illuminates biogeography and the fossils record. Science 307:580-584, 2005.
  558. Buckley-Beason, V.A., Johnson, W.E., Nash, W.G., Stanyon, R., Menninger, J.C. Driscoll, c.A., Howard, J., Bush, M. Page, J.E., Roelke, M.E., Stone, G., Martelli, P.P., Wen, C., Ling, L., Duraisingam, R.K., Lam, P.V. and O’Brien, S.J.: Molecular Evidence for Species-Level Distinctions in Clouded Leopards. Curr Biol 16:2371-2376, 2006.
  559. O’Brien, S.J.: Cats. Curr Biol. 14:R988-R990, 2004.
  560. O’Brien, S.J., and Johnson, W.: Big cat genomics. Ann. Rev. Genomic and Human Genetics 6:407-429, 2005.
  561. Hendel, H., Winkler, C., An, P., Binns-Roemer, E., Nelson, G., Haumont, P., O’Brien, S.J., Khalilli, K. Zagury, D., Rappaport, J., and Zagury, J.-F.: Validation of Genetic Case-Control Studies in AIDS and Application to the CX3CR1 Polymorphism 26, 507-511, 2001.
  562. Bashirova, A.A., Bleiber, G., Qi, Y., Hutcheson, H., Yamashita, T., Johnson, R.C., Cheng, J., Alter, G., Goedert, J., Buchbinder, S., Hoots, K., Vlahov, D., May, M., Maldarelli, F., Jacobson, L., O’Brien, S.J., Telenti, A., and Carrington, M.: Consistent effects of TSG101 genetic variability on multiple outcomes of exposure to human immunodeficiency virus type 1 J. Virol. 80:6757-6763. 2006
  563. Vazquez-Salat, N., Yuhki, N., Beck, T., O’Brien, S.J., and Murphy, W.J.: Gene conservation between mammalian CCR2 and CCR5 chemokine receptor genes: A potential mechanism for receptor dimerization. Genomics 90:213-224, 2007.
  564. Guo, X-C, O’Brien, S.J., Winkler, C., Scott, K., Hutcheson, H., David, V., Kessing, B., Zheng, Y-M., Liao, J., Lui, Y., de The, G., Zeng, Y.: Association study of chromosome 4 STRs polymorphisms with nasopharyngeal carcinoma. Hereditas (Beijing) 28: 783-790, 2006.
  565. Smith, M.W., and O’Brien, S.J.: Mapping by Admixture Disequilibrium: Advances, Limits and Guidelines. Nature Genetics Reviews. 6: 623-632, 2005.
  566. Murphy, W.J., Agarwala, R., Schaffer, A.A., Stephens, R., Smith, Jr., C., Crumpler, N.J., David, V.A., and O’Brien, S.J.: A rhesus macaque radiation hybrid map and comparative analysis with human genome. Genomics 86: 383-395, 2005.
  567. Schmidt-Küntzel, A., Eizirik, E., O’Brien, S.J., Menotti-Raymond, M.: Tyrosinase and tyrosinase related protein 1 alleles specify domestic cat coat color phenotypes of the albino and brown loci. J Hered. 2005 Jul-Aug;96(4):289-301. Epub 2005 Apr 27.
  568. Shrestha, S., Stradthdee, S.A., Galai, N., Oleksyk, T., Fallin, D., Mehta. S., Schaid, D., Vlahov, D., O’Brien, S.J., and Smith, M.W.: Behavioral risk exposure and host genetics of susceptibility to HIV-1 infection. J Infect Dis 193: 16-26, 2006.
  569. Murphy, W.J., Larkin, D.M., Everts-van de Wind, A., Bourque, G., Tesler, G., Auvil, L., Beever, J.E., Chowdhary, B.P., Galibert, F., Gatzke, L., Hitte, G., Meyers, S.N., Ostrander, A.E., Pape, G., Parker, H.G., Raudsepp, T., Rogatcheva, M.B., Schook. L.B., Skow, L.C., Welge, M., Womack, J.E., O’Brien, S.J., Pevzner, P.A., Lewin, H.A.: Dynamics of mammalian chromosome evolution inferred from multispecies comparative maps. Science 309:613-617, 2005.
  570. O’Brien, S.J., Luo, S.-J., Kim, J.-H., and Johnson, W.E.: Molecular genetic analysis reveals six living subspecies of tiger, Panthera tigris. Cat News 42: 6-8.
  571. Walsh, E.C., Sabeti, P., Hutcheson, H., Fry, B., Schaffner, S.F., de Bakker, P., Varilly, P., Roy, J., Cooper, R., Zeng, Y., Guo, Xiuchan, Lander, E.S., O’Brien, S.J., Altshuler, D.: Searching for signals of evolutionary selection in 168 genes related to immune function. Hum Genet. 199: 92-102, 2006.
  572. Pereira, M.J.R., Rebelo, H., Teeling, E.C., O’Brien, S.J., New, T., Bu, S.S.H., Swe, KM., Mie, M.K., Bates, P.J.: Status of the world’s smallest mammal, the bumble-bee bat Craseonycteris thonglongyai, in Myanmar. ORYX 40: 456-463, 2006.
  573. Lind, J.M., Hutcheson, H.B., Williams, S.M., Moore, J.H., Essex, M., Ruiz-Pesini, E., Wallace, D.C., Tishkoff, S.A., O’Brien, S.J., and Smith, M.W.: Elevated male European and female African contributions to the genomes of African American individuals. Hum Genet. 120: 713-722, 2007.
  574. Luo, S.J., Kim, J-H., Johnson, W. E., Miquelle, D. G., Huang, S-G., Pan W-S., Smith. J. L. D., O’Brien, S.J.: Proceedings in phyogeography and genetic ancestry of Tigers (Panthera tigris) in China and across the range. Zoological Research 27:441-448, 2006.
  575. 575. Sarno, R.J., Bonaciuc, C., Gonzalez, G., Zazpata, B., O’Brien, S.J., Johnson, W.E.: Molecular genetic evidence for social group disruption of wild vicunas Vicugna vicugna captured for wool harvest in Chile SMALL RUMINANT RESEARCH Volume: 84 Issue: 1-3 Pages: 28-34 Published: JUN 2009
  576. Oleksyk, T.K., Zhao, K., Gilbert, D.A., de La Vega, F.M., O’Brien, S.J., Smith, M.W.: Identifying Selected Regions from Heterozygosity and Divergence Using a Light-Coverage Genomic Dataset from Two Human Populations. PLoS ONE 3:e1712, 2008.
  577. Helgadottir, A., Manolescu, A., Helgason, A., Thorleifsson, G., Thorsteinsdottir, U., Gudbjartsson, D., Gretarsdottir, S., Magnusson, K.P., Gudmundsson, G., Hicks, A., Jonsson, T., Grant, S.F.A., Sainz, F., O’Brien, S.J., Sigurlaug Sveinbjornsdottir, S., Valdimarsson, E.M., Matthiasson, S.E., Levey, A.I., Thorgeirsson, G., Abrahamson, J., Reilly, M., Zafari, M., Wolfe, M., Gudnason, V., Quyyumi, A.A., Topol, E.J., Rader, D., Gulcher, J., Hakonarson, H., Kong, A., Stefansson, K.: A variant of the gene encoding Leukotriene A4 Hydrolase confers ethnic specific risk of myocardial infarction. Nature Genetics 38: 68-74, 2006.
  578. Gao, X., Single, R.M., Karacki, P., Marti, D., O’Brien, S.J.: Diversity of MICA and linkage disequilibrium with HLA-B in two North American populations. Human Immunol 67: 152-158, 2006.
  579. Perez-Gelabert, D.e., Roca, A.L., O’Brien, S.J., Menninger, J., Nash, W., Pontius, J., and Yuhki, N.: Chromosomal assignment and genomic analysis of endogenous retrovirus RD-114 indomestic and wild cats.
  580. Roca, A.L., and. O’Brien, S.J.: Genetic inferences from Afrotheria and the evolution of elephants. Curr Opin Genet Dev 15:652-659. 2005.
  581. Modi, W.S., Scott, K., Goedert, J.J., Vlahov, D., Buchbinder, S., Detels, R., Donfield, S., O’Brien, S.J., and Winkler, C.: Haplotype analysis of the SDF-1 (CXCL12) gene in a longitudinal HIV-1/AIDS cohort study. Genes and Immunity.6:691-698, 2006.
  582. 582. DRISCOLL, CARLOS A., DAVID W. MACDONALD,and STEPHEN J. OBRIEN From Wild Animals to Domestic Pets, an Evolutionary View of Domestication in “In the Light of Evolution III: Two Centuries of Darwin”, by National Research Council, John C. Avise, and Francisco J. Ayala ED 2009.
  583. Sabeti, P.C., Walsh, E., Schaffner, S., Varilly, P., Fry, B., Cullen, M., Mikkelsen, T., Roy, J., Patterson, N., Cooper, R., Altshuler, D., and Lander, E.S.: The case for selection at CCR5Δ32. PLoSBiol.3:1963-1969, 2005.
  584. Capelli, C., MacPhee, R.D.E., Roca, A.L., Brisighelli, F., Georgiadis, N., O’Brien, S.J., and Greenwood, A.D.: A nuclear DNA phylogeny of the woolly mammoth (Mammuthus primigenius). Mol Phylogenet Evol 40: 620-627, 2006.
  585. Springer, M.S., Burk-Herrick, A., Meredith, R., Eizirik, E., Teeling, E., O’Brien, S.J., Murphy, W.J.: The adequacy of morphology for reconstructing the early history of placental mammals. Syst Biol. 2007 Aug;56(4):673-84.
  586. Fyfe, J.C., Menotti-Raymond, M., David, V.A., Brichta, L., Schäffer, A.A., Agarwala, R., Murphy, W.J., Wedemeyer, W.J., Gregory, B.L., Buzzell, B.G., Drummond, M.C., Wirth, B., O’Brien, S.J.: An approximately 140-kb deletion associated with feline spinal muscular atrophy implies an essential LIX1 function for motor neuron survival. Genome Res. 2006 Sep;16(9):1084-90. Epub 2006 Aug 9.
  587. O’Brien, S.J.: The dog and its genome. Nature 438:740, 2005.
  588. Welzel, T.M., Gao, X., Pfeiffer, R., Martin, M.P., O’Brien, S.J., Goedert, J.J., Carrington, M. and O’Brien, T.R.: HLA Bw4 alleles and HIV-1 transmission in heterosexual couples. AIDS 21: 225-229, 2007.
  589. Napolitano, C, Bennett, M., Johnson, W.E., O’Brien, S.J., Marquet, P.A., Barria, I., Poulin, E., and Iriarte, A.: Ecological and biogeographical inferences on two sympatric and enigmatic Andean cat species using genetic identeification of faecal samples. Mol Ecol 17: 678-690, 2008.
  590. Hutcheson, H., Lautenberger, J., Nelson, G., Pontuis, J.J., Kessing, B.D., Smith, M.W., Johonson, R., Stephens, R., Phair, J., Goedert, J., Donfield., S., and O’Brien, S.J.: Detecting AIDS Restriction Genes: From Candidate Genes to Genome-Wide Association Discovery. Vaccine 26: 2951-2965, 2008.
  591. Thio, C.L., Astemborski, J., Bashirova, A., Mosbruger, T., Greer, S., Witt, M.D., Goedert, J.J., Hilgartner, M., Majeske, A., O’Brien, S.J., Thomas, D.L., and Carrington, M.: Genetic protection against HBV conferred by CCR5Δ32: evidence that CCR5 contributes to viral persistence. J Virol 81:441-445, 2007.
  592. O’Brien, S.J., Troyer, J., Roelke, M., Pecon-Slattery, J. and Marker, L.: Plagues and adaptations: Lessons from the Felidae modes for AIDS and SARS. Biol Conserv 131:255-267, 2006.
  593. Nash, W.G., Menninger, J.C., Padilla-Nash, H. M. and O’Brien, S.J.: Ancestral carnivore karyotype (2n=38) lives today in ringtails. J Hered 99: 241-253, 2008.
  594. Javanbakht, H., An, P., Gold, B., Petersen, D.C., O;hUigin,C., Nelson, G.W., O’Brien, S.J., Kirk, G.D., Detels, R., Buchbinder, S., Donfield, S., Shulenin, S., Song, B., Perron, J.J., Stremlau, M., Sodroski, J., Dean, M., and Winkler, C Effects of human TRIM5alpha polymorphisms on antiretroviral function and susceptibility to human immunodeficiency virus infection.Virology 354: 15-27, 2006
  595. Qi, Y., Martin, M.P., Gao, X., Jacobson, L., Goedert, J.J., Buchbinder, S., Kirk, G.D., O’Brien, S.J., Trowsdale, J., and Carrington, fM.: KIR/HLA Pleiotropism: Protection against Both HIV and Opportunistic Infections. PLoS Pathog. 2:741-745-2006.
  596. Antunes, A., Troyer, J.L., Roelke, M.E., Pecon-Slattery, J., Packer, C., Winterbach, C., Winterbach, H., Hemson, G., Frank, L., Stander, P., Siefert, L., Driciru, M., Funston, P.J., Alexander, K.A., Prager, K.C., Mills, G., Wildt, D., Bush, M., O’Brien, S.J., Johnson, W.E.: The evolutionary dynamics of the lion Panthera leo revealed by host and viral population genomics. PLoS Genet. 2008 Nov;4(11):e1000251. Epub 2008 Nov 7.
  597. Ishida, Y., David, V.A., Eizirik, E., Schäffer, A.A., Neelam, B.A., Roelke, M.E., Hannah, S.S., O’brien, S.J., Menotti-Raymond, M.: A homozygous single-base deletion in MLPH causes the dilute coat color phenotype in the domestic cat. Genomics. 2006 Dec;88(6):698-705.
  598. Modi, W.S., Lautenberger, J., Scott, K., Ping, A., Goedert, J.J., Kurt, G.D., Buchbinder, J., Donfield, S., O’Brien, S.J., and Winkler, C.: Genetic variation in the CCL18 – CCL3 – CCL4 chemokine gene cluster influences HIV-1 transmission and AIDS disease progression. Am J Hum Genet 79:120-128. 2006.
  599. Perelman, P.L., Graphodatsky, A.S., Dragoo, J.W., Serdyukova, N.A., Stone, G., Cavagna, P., Menotti, A., Nie, W., O’Brien, P.C., Wang, J., Burkett, S., Yuki, K., Roelke, M.E., O’Brien, S.J., Yang, F., Stanyon, R.: Chromosome painting shows that skunks (Mephitidae, Carnivora) have highly rearranged karyotypes. Chromosome Res. 2008;16(8):1215-31. Epub 2008 Nov 25.
  600. O’Brien, S.J. and Johnson, W.E.: The evolution of cats. Genomic paw prints in the DNA of the world’s wild cats have clarified the cat family tree and uncovered several remarkable migrations in their past. Sci Am 297:68-75, 2007.
  601. Pontius, J. U., Mullikin, J. C., Smith, D., Lindblad-Toh, K., Gnerre, S., Clamp, M., Stephens, R., Neelam, B., Volfovsky, N., Schäffer, A. A., Agarwala, R., Narfström K., Murphy, W. J., Giger, U., Roca, A. L., O’hUigin, C., Antunes, A., Menotti-Raymond, M., Yuhki, N., Pecon-Slattery, J., Johnson, W. E., Driscoll, C. and O’Brien, S.J.: Initial sequence and comparative analysis of the cat genome. Genome Research 11: 1675-1689, 2007.
  602. Driscoll, C.A., Menotti-Raymond, M., Roca, A.L., Hupe, K., Johnson, W.E., Geffen, E., Harley, E.H., Delibes, M., Pontier, D., Kitchener, A.C., Yamaguchi, N., O’brien, S.J., Macdonald, D.W.: The Near Eastern origin of cat domestication. Science. 2007 Jul 27;317(5837):519-23.
  603. Menotti-Raymond, M., David, V.A., Schäffer, A.A., Stephens, R., Wells, D., Kumar-Singh, R., O’Brien, S.J., Narfström, K.: Mutation in CEP290 discovered for cat model of human retinal degeneration. J Hered. 2007 May-Jun;98(3):211-20. Epub 2007 May 16.
  604. Murphy, W.J., Davis, B., David, V.A., Agarwala, R., Schäffer, A.A., Pearks Wilkerson, A.J., Neelam, B., O’Brien, S.J., Menotti-Raymond, M.: A 1.5-Mb-resolution radiation hybrid map of the cat genome and comparative analysis with the canine and human genomes. Genomics. 2007 Feb;89(2):189-96. Epub 2006 Sep 25.
  605. Martin, M. P., Qi, Y., Gao, X-J., Brown, E. E., Phair, J., Goedert, J. J., Buchbinder, S., Kirk, G. D., O’Brien, S.J., Parham, P., McVica. E. W., Carrington, M.: Innate partnership of HLA-B and KIR3DL1 subtypes against HIV-1. Nat Genet 39:733-740, 2007.
  606. Truelove, A. L., Oleksyk, T. K., Shrestha, S., Thio, C. L., Goedert, J. J., Donfield, S. M., Kirk, G.D., Thomas, D. L., O’Brien, S.J., and Smith, M. W.: Evaluation of IL10, IL19 and IL20 gene polymorphisms and chronic hepatits B infection outcome. Int J Immunogenet 35:255-264, 2008.
  607. Luo, S-J., Cai, Q-X., David, V. A., Zhang, Li., Martelli, P., Lim, N. T-L., Ferrand, N., Chin, S-C., Guabert, P., Ramos, M., J., O’Brien, S.J., Antunes, A., Johnson, W. E.: Isolation and characterization of microsatellite markers in pangolias (mammalia, Pholidota, Manis spp). Mol Ecol Notes 7:269-272, 2007.
  608. Menotti-Raymond, M., O’Brien, S.J.: The domestic cat, Felis catus, as a model of hereditary and infectious disease. In: Source Book for Models for Biomedical Research. Michael Conn ed. Humana Press Inc., Totawa, NJ. pp 221-232. 2008.
  609. Bar-Gal, G.K., Kessing, B., Pecon-Slattery, J., Tetu, S., VandeWoude, S., Hoover, E. and O’Brien, S.J.: Phylo-diversity of feline immunodeficiency virus (FIV) in domestic cats. In preparation.
  610. An., P., Duggal, P., Wang, L.H., O’Brien, S.J., Donfield, S., Goedert, J.J., Phair, J., Buchbinder, S., Kirk, G.D., and Winker, C.A.: Polymorphisms of CUL5 area ssociated with CD4+ T cell loss in HIV-1 infected individuals. PLoS Genetics 3: e19, 2007.
  611. O’Brien, S.J, An interview with. Q&A. Curr Biol. 17: R152-R154, 2007.
  612. Menotti-Raymond, M., David, V.A., Pflueger, S.M., Lindblad-Toh, K., Wade, C.M., O’Brien, S.J., Johnson, W.E.: Patterns of molecular genetic variation among cat breeds. Genomics. 2008 Jan;91(1):1-11. Epub 2007 Oct 25.
  613. Kehler, J.S., David, V.A., Schäffer, A.A., Eizirik, E., Ryugo, D.K., Hannah, S.S., O’Brien, S.J., Menotti-Raymond, M. Four independent mutations in the feline fibroblast growth factor 5 gene determine the long-haired phenotype in domestic cats. J Hered. 98:555-66, 2007.
  614. Miller-Butterworth, C.M., Murphy, W.J., O’Brien, S.J., Jacobs, D.S., Springer, M.S., and Teeling, E.C.: A family matter: conclusive resolution of the taxonomic position of the long-fingered bats, miniopterus. Mol Biol Evol 24:1553-1561, 2007.
  615. Luo, S.J., Johnson, W.E., David, V.A., Menotti-Raymond, M., Stanyon, R., Cai, Q.X., Beck, T., Yuhki, N., Pecon-Slattery, J., Smith, J.L., O’Brien, S.J.: Development of Y chromosome intraspecific polymorphic markers in the Felidae. J Hered. 2007;98(5):400-13. Epub 2007 Jul 23.
  616. An, P. Wang, L.H., Hutcheson, H., Nelson, G., O’Brien, S.J., Donfield, S., Goedert, J.J., Phair, J., Buchbinder, S., Kirk, G.D., and Winkler, C.A.: Regulatory polymorphisms in the Cyclophilin A gene, PPIA accelerate progression to AIDS. PLoS Pathogens 3:849-857, 2007.
  617. Yuhki, N., Beck, T., Stephens, R., Neelam, B., and O’Brien, S.J.: Comparative genomic structure of human, dog, cat MHC: -HLA, DLA, and FLA-. J Hered 98:390-399, 2007.
  618. Antunes, A., Pontius, Ramos, M.J., O’Brien, S.J. and Johnson, W.E.: Mitochondrial introgressions into the nuclear genome of the domestic cat. J Hered 98:414-420, 2007.
  619. Springer, M.S., Murphy, W.J., Eizirik, E., Madsen. O., Scally, M., Douady, C.J., Teeling. E.C., Stanhope, M.J., de Jong, W.W., and O’Brien, S.J.: A molecular classification for the living orders of placental mammals of the phylogenetic placement of primates. In: Primate Origins: Adaptations and Evolution. (Ravosa, M.J. and Dagosto, M. Eds.), Springer, 2006.
  620. Wilting, A., Buckley-Beason, V.A., Feldhaar, H., Gadau, J., O’Brien, S.J., and Linsenimair, K.D.: Clouded leopard phylogeny revisited: support for species recognition and population division between Borneo and Sumatra. Front Zool 4:15, 2007.
  621. Troyer, J.L., VandeWoude, S., Slattery, J., McIntosh, C., Franklin, S., Antunes, A., Johnson, W., and O’Brien, S.J. FIV-cross-species transmission: an evolutionary prospective. Vet Immunol Immunopathol 123: 159-166, 2008.
  622. Baena, A., Mootnick, A.R., Falvo, J.V. Tystskova, A.V., Ligeiro, F., Diop, O.M., Brieva, C., Gagneux, O’Brien, S.J., Ryder, A.O., and Goldfeld, A.E. Primate TNF promoters reveal makers of phylogeny and evolution of innate immunity. PLoS ONE 2:e621, 2007.
  623. Martin, M.P., Pascal, V., Yeager, M., Phair, J., Kirk, G.D., Hoots, K., O’Brien, S.J., Anderson, S., and Carrington, M. A mustation in KIR3DS1 that results in truncation and lack of cell surface expression. Immunogenetics 59: 823-829, 2007.
  624. Menotti-Raymond, M.A., David, V.A., and O’Brien, S.J. STR based forensic analysis of felid samples from domestic and exotic cats. In: Non-Human DNA Typing: Theory and Casework Applications, Coyle, H. (Ed.), Marcel Dekker, Inc., New York, 2008.
  625. Wilting, A., Feldhaar, H., Buckley-Beason, V.A., Linsenmair, K.E., and O’Brien, S.J.: Two modern species of clouded leopards: a molecular perspective. Cat News 47: 10-11, 2007.
  626. Cunningham, M.W., Brown, M.A., Shindle, D.B., Terrell, S.P., Hayes, K.A., Ferree, B.C., McBride, R.T., Blankenship, E.L., Jansen, D., Citino, S.B., Roelke, M.E., Kiltie, R.A., Troyer, J.L., O’Brien, S.J.: Epizootiology and management of feline leukemia virus in the Florida puma. J Wildl Dis. 2008 Jul;44(3):537-52.
  627. Brown, M., Cunningham, M.W., Roca, A.L., Troyer, J.L., Johnson, W.E. and O’Brien, S.J.: Genetic characterization of emerging feline leukemia virus in the free-ranging Florida panter population. Emerg Infect Dis 14: 252-259, 2008.
  628. Roelke, M.E., Brown, M.A., Troyer, J.L., Winterbach, H., Winterbach, C., Hemson, G., Smith, D., Johnson, R.C., Pecon-Slattery, J., Roca, A.L., Alexander, K.A., Klein, L., Martelli, P., Krishnasamy, K., O’Brien, S.J.: Pathological manifestations of feline immunodeficiency virus (FIV) infection in wild African lions. Virology. 2009 Jul 20;390(1):1-12.
  629. Pecon-Slattery, J., McCracken, C., Troyer, J., VandeWoude, S., Roelke, M., Sondgareth, K., Winterbach, C., Winterbach, H., and O’Brien, S.J.: Genome organization, sequence divergence, and recombination of feline immunodeficiency virus from lions in the wild. BMC Genomics 9:66, 2008.
  630. Zeng, Z., Guan, L., An., P., Sun, S., O’Brien, S.J., and Winkler, C.A.: A population based study to investigate the host genetic facdtors associated with Hepatitus B infection and pathogenesis in the Chinese population. BMC Infect Dis 8:1, 2008.
  631. Driscoll, C.A., Yamaguchi, N., Bar-Gal, G.K., Roca, A.L., Luo, S., Macdonald, D.W., O’Brien, S.J.: Mitochondrial phylogeography illuminates the origin of the extinct caspian tiger and its relationship to the amur tiger. PLoS One. 2009;4(1):e4125. Epub 2009 Jan 14.
  632. Luo, S.J., Johnson, W.E., Martenson, J., Antunes, A., Uphyrkina. O., Martelli, P., Tarasov, V., Smith, J.L.D., O’Brien, S.J.: Subspecies genetic assignments of worldwide captive tigers increase conservation value of captive populations. Curr Biol 18:592-596, 2008.
  633. Fisher, R.W., Ambrose, Z., Fritz, E.A., Hartmann, C.J., Hensley, L.E., Huggins, J.W., Jahrling, P.B., KewalRamani, V.N., Mucker, E.M., Paragas, J., Young, H.A., and O’Brien, S.J.: The CCR5 chemokine receptor is not required for monkeypox or variola entry into human monocytes. In prep
  634. Hendrickson, S.L., Jacobson, L.P., Nelson, G., Phair, J.P., Johnson, R., Margolick, J.B., Detels, R., Rinaldo, C., and O’Brien, S.J.: Host Genetic Influences on Highly Active Antiretroviral Therapy Efficacy and AIDS-Free Survival J Acquir Immune Defic Syndr 48:263-271, 2008.
  635. Hendrickson, S.L., Hutcheson, H.B., Ruiz-Pesini, E., Poole, J.C., Lautenberger, J., Sezgin, E., Kingsley, L., Goedert, J.J., Vlahov, D., Donfield, S., Wallace, D.C., O’Brien, S.J.: Mitochondrial DNA haplogroups influence AIDS progression. AIDS. 2008 Nov 30;22(18):2429-39.
  636. Eizirik, E., Johnson, W.E. and O’Brien, S.J.: Molecular systematics and revised classification of the family Felidae (Mammalia, Carnivora). J Mammol In Press.
  637. 637. Trigo, T.C., Freitas, T.R.O., Kunzler, G., Cardoso, L., Silva, J.C.R., Johnson, W.E., O’Brien, S.J., Bonatto, S.L., Eizirik, E.: .: Inter-species hybridization among Neotropical cats of the genus Leopardus, and evidence for an introgressive hybrid zone between L-geoffroyi and L-tigrinus in southern Brazil MOLECULAR ECOLOGY Volume: 17 Issue: 19 Pages: 4317-4333 Published: OCT 2008
  638. Yuhki, N., Mullikin, J., Beck, T., Stephens, R., and O’Brien, S.J.: Sequences, annotation and single nucleotide polymorphism of the major histocompatibility complex in the domestic cat.PLoS One 3:e2674, 2008.
  639. da Fonseca, R., Johnson, W.E., O’Brien, S.J., Ramos, M.J., and Antunes, A.: The adaptive evolution of the mammalian mitochondrial genome. BMC Genomics 9:119, 2008.
  640. Pontius, J.U., O’Brien, S.J.: Genome Annotation Resource Fields–GARFIELD: a genome browser for Felis catus. J Hered. 2007;98(5):386-9. Epub 2007 Jul 23.
  641. O’Brien, S.J., Johnson, W., Driscoll, C., Pontius, J., Pecon-Slattery, J., Menotti-Raymond, M.: State of Cat Genomics. Trends in Genetics 24: 268-279, 2008.
  642. Coomber, N., David, V.A., O’Brien, S.J., Menotti-Raymond, M.: Validation of a short tandem repeat multiplex typing system for genetic individualization of domestic cat samples. Croat Med J. 2007 Aug;48(4):547-55.
  643. Pecon-Slattery, J., Troyer, J.L., Johnson, W.E. O’Brien, S.J.: Evolution of feline immunodeficiency virus in Felidae: implications for human health and wildlife ecology. Vet Immunol Immunopathol 123:32-44, 2008.
  644. Pontius, J.U., and O’Brien, S.J.: Use of online resources for the annotation of the Felis catus genome. IFRRS J Submitted.
  645. Benson JF, Hostetler JA, Onorato DP, Johnson WE, Roelke ME, O’Brien SJ, Jansen D, Oli MK. Intentional genetic introgression influences survival of adults and subadults in a small, inbred felid population. J Anim Ecol. 80(5):958-67. 2011.
  646. Murphy, W.J. and O’Brien, S.J.: Designing and optimizing comparative anchor primers for comparative gene mapping and phylogenetic inference. Nature Protocols 2: 3022-3030, 2007.
  647. Krause, J., Unger, T., Noçon, Malaspinas, A-S., Stiller, M., Kolokotronis, S-O., Soibelizon, L., Spriggs, H., Dear, P.H., Briggs, A.W., Bray, S.C.E., O’Brien, S.J., Rabeder, G., Matheus, P., Cooper, A., Slatkin, M., Pääbo, S., Hofreiter, M.: Mitrochondrial genomes reveal an explosive radiation of extinct and extant bears near the Miocene-Pliocene boundary. BMC Evol Biol 8:220, 2008.
  648. Roelke, M.E., Johnson, W.E., Millán, Palomares, F., Revilla, E., Rodríguez, Calzada, Ferreras, P., León-Vizcaíno, L., Delibes, M., O’Brien, S.J.: Exposure to disease agents in the endangered Iberian lynx (Lynx pardinus). Euro J Wildl Res 54:171-178, 2008.
  649. Eizirik, E., Johnson, W.E., and O’Brien, S.J.: In: Manejo e Conservação de Carnívoros Neotropicais. Definindo uniadades evolutivamente significativas e unidades de manejo para a conservação de carnívoros neotropicais. Morato, R.G., Rodrigues, F.H.G., Eizirik, E., Mangini, P.R., Cascelli de Azevedo, F.C., Marinho-Filho, J. (Eds.) pp. 47, 2007.
  650. Johnson, W.E., Eizirik, E., Waits, L., and O’Brien, S.J. In: Manejo e Conservação de Carnívoros Neotropicais. Molecular ecology and carnivore conservation: The applications of molecular techniques for inferring identify kinship, and social structure in the neotropics. Morato, R.G., Rodrigues, F.H.G., Eizirik, E., Mangini, P.R., Cascelli de Azevedo, F.C., Marinho-Filho, J. (Eds.) pp. 67, 2007.
  651. Werdelin, L., O’Brien, S.J., Johnson, W.E., Yamaguchi, N.: Phylogeny and evolution of cats (Felidae). Macdonald, D., and Loverage A. (eds.). In: Biology and Conservation of Wild Felids. Oxford University Press. 2009 In Press
  652. Graphodatsky, A.S., Perelman, P., Sokolovskaya, N.V. Beklemisheva, V.R., Serdukova, N.A., O’Brien, S.J., Ferguson-Smith, M.A., Yang, F.: Phylo-genomics of the dog and fox family (Canidae, Carnivora) revealed by chromosome painting. Chromosome Res 16: 129-143, 2008.
  653. Luo, S-J., Johnson, W.E., Smith, J.L.D., O’Brien, S.J.: What is a tiger? Genetics and PhyogeographyThe Science,Politics, and Conservation of Panthera tigris . In: Tigers of the World.Ed. Tilson, R. and P.J Nyhus pp. 35-53 Academic Press San Diego CA 2010.
  654. Münk, C., Beck, T., Zielonka, J., Hotz-Wagenblatt, A., Chareza, S., Battenberg, M., Thielebein, J., Cichutek, K., Bravo, I.G., O’Brien, S.J., Löchelt, M., Yuhki, N.: Functions, structure and read-through alternative splicing of feline APOBEC3 genes. Genome Biol 9:R48, 2008.
  655. Culver, M., P. W. Hedrick, et al. (2008). “Estimation of the bottleneck size in Florida panthers.” Animal Conservation 11(2): 104-110.
  656. Shearer, W.T., Nelson, G.W., McIntosh, K., Thompson, B., Lu, M., Rich, K.C., LaRussa, P.S., Blattner, A., Brouwers, P., and O’Brien, S.J.: Association between genotypes and infant HIV disease progression: The women and infants transmission study. In prep
  657. O’Brien, S.J.: The platypus genome unraveled. Cell 133:953-955, 2008.
  658. Schmidt-Kuntzel, A., Nelson, G., David, V.A., Schaffer, A.A., Eizirik, E., Roelke, M.E., Kehler, J.S., Hannah, S.S., O’Brien, S.J., Menotti-Raymond, M.: A domestic cat X chromosome linkage map and the sex-linked orange locus: mapping of orange, multiple origins and epistasis over nonagouti. Genetics. 2009 Apr;181(4):1415-25.
  659. Li, X., Glaser, D., Li, W., Johnson, W.E., O’Brien, S.J., Beauchamp, G.K., Brand, J.G.: Analyses of sweet receptor gene (Tas1r2) and preference for sweet stimuli in species of Carnivora. J Hered. 2009 Jul-Aug;100 Suppl 1:S90-100..
  660. Driscoll, C.A., Clutton-Brock, J., Kitchener, A.C., O’Brien, S.J.: The Taming of the cat. Genetic and archaeological findings hint that wildcats became housecats earlier–and in a different place–than previously thought. Sci Am. 2009 Jun;300(6):68-75.
  661. Menotti-Raymond, M., David, V.A., Schäffer, A.A., Tomlin, J.F., Eizirik, E., Phillip, C., Wells, D., Pontius, J.U., Hannah, S.S., O’Brien, S.J.: An autosomal genetic linkage map of the domestic cat, Felis silvestris catus. Genomics. 2009 Apr;93(4):305-13.
  662. Guo, X, O’Brien, S.J., Zeng, Y., Nelson, G.W., and Winkler, C.A.: GSTM1 and GSTT1 gene deletions and the risk for nasopharyngeal carcinoma in Han Chinese. Epidemiol. Biomarkers Prev. 17: 1760-1763, 2008.
  663. Urban, T.J., Weintrob, A.C., Fellay, J., Colombo, S., Shianna, K.V., Gumbs, C., Rotger, M., Pelak, K., Dang, K.K., Detels, R., Martinson, J.J., O’Brien, S.J., Letvin, N.L., McMichael, A.J., Haynes, B.F., Carrington, M., Telenti, A., Michael, N.L., Goldstein, D.B.: CCL3L1 and HIV/AIDS susceptibility. Nat Med. 2009 Oct;15(10):1110-2.
  664. Guo, X., Johnson, R.C., Deng, H., Liao, J., Guan, L., Nelson, G.W., Tang, M., Zheng, Y., de The, G., O’Brien, S.J., Winkler, C.A., Zeng, Y.: Evaluation of nonviral risk factors for nasopharyngeal carcinoma in a high-risk population of Southern China. Int J Cancer. 2009 Jun 15;124(12):2942-7.
  665. Roca, A.L., Georgiadis, N., and O’Brien, S.J. Cyto-nuclear genomic dissociation and the African elephant species question. Quat Int 169-170: 4-16, 2007.
  666. Hendrickson, S., Nelson, G.W. and O’Brien, S.J. The Explained Fraction as a Statistical “Yardstick” for Genetic Association Studies. In preparation.
  667. Brown, M.A., Troyer, J.L., Pecon-Slattery, J., Roelke, M.E., O’Brien, S.J.: Genetics and pathogenesis of feline infectious peritonitis virus. Emerg Infect Dis. 2009 Sep;15(9):1445-52.
  668. Sezgin, E., Lind, J.M., Shrestha, S., Hendrickson, S., Goedert, J.J., Donfield, S., Kirk, G.D., Phair, J.P., Troyer, J.L., O’Brien, S.J., Smith, M.W. 2009: Association of Y chromosome haplogroup I with HIV progression, and HAART outcome. Hum Genet. 125(3):281-94
  669. Oleksyk, T.K., Smith, M.W., and O’Brien, S.J. Genome-wide scans for selection. 2010 Philos Trans R Soc Lond B 365(1537):185-205
  670. Oleksyk, T.K., Shrestha, S., Truelove, A.L., Goedert, J.J., Donfield, S.M., Phair, J., Mehta, S., O’Brien, S.J., Smith, M.W.: Extended IL10 haplotypes and their association with HIV progression to AIDS. Genes Immun. 2009 Jun;10(4):309-22.
  671. Lewin, H.A., Larkin, D.M., Pontius, J., O’Brien, S.J.: Every genome sequence needs a good map. Genome Res. 2009 Nov;19(11):1925-8
  672. Hendrickson, S.L., Kingsley, L.A., Ruiz-Pesini, E., Poole, J.C., Jacobson, L.P., Palella, F.J., Bream, J.H., Wallace, D.C., O’brien, S.J.: Mitochondrial DNA haplogroups influence lipoatrophy after highly active antiretroviral therapy. J Acquir Immune Defic Syndr. 2009 Jun 1;51(2):111-6.
  673. Herbeck, J.T., Gottlieb, G.S., Winkler, C.A., Nelson, G.W., An, P., Maust, B.S., Wong, K.G., Troyer, J.L., Goedert, J.J., Kessing, B.D., Detels, R., Wolinsky, S.M., Martinson, J., Buchbinder, S., Kirk, G.D., Jacobson, L.P., Margolick, J.B., Kaslow, R.A., O’Brien, S.J., Mullins, J.I.: Multistage genomewide association study identifies a locus at 1q41 associated with rate of HIV-1 disease progression to clinical AIDS. J Infect Dis. 2010 Feb 15;201(4):618-26.
  674. LaRue, R.S., Andresdottir, V., Blanchard, Y., Conticello, S.G., Derse, D., Emerman, M., Greene, W.C., Jonsson, S.R., Landau, N.R., Lochelt, M., Malik, H.S., Malim, M.H., Munk, C., O’Brien, S.J., Pathak, V.K., Strebel, K., Wain-Hobson, S., Yu, X.F., Yuhki, N., Harris, R.S.: Guidelines for naming nonprimate APOBEC3 genes and proteins. J Virol. 2009 Jan;83(2):494-7. Epub 2008 Nov 5.
  675. O’Brien, S.J. Stewardship of Human Biospecimens, DNA, Genotype, and Clinical Data in the GWAS Era. Annu. Rev. Genomics Hum. Genet. 2009. 10:193–209. http://arjournals.annualreviews.org/doi/pdf/10.1146/annurev-genom-082908-150133?cookieSet=1
  676. Pontius, J.U., O’Brien, S.J. Artifacts of the 1.9x feline genome assembly derived from the feline-specific satellite sequence. J Hered. 2009 Jul-Aug;100 Suppl 1:S14-8. Epub 2009 Jun 16.
  677. Menotti-Raymond, M., David, V.A., Eizirik, E., Roelke, M.E., Ghaffari, H., O’Brien, S.J. Mapping of the domestic cat “SILVER” coat color locus identifies a unique genomic location for silver in mammals. J Hered. 2009 Jul-Aug;100 Suppl 1:S8-13. Epub 2009 Apr 27.
  678. Tang M, Zeng Y, Poisson A, Marti D, Guan L, Zheng Y, Deng H, Liao J, Guo X, Sun S, Nelson G, de Thé G, Winkler CA, O’Brien SJ, Carrington M, Gao X. Haplotype-dependent HLA susceptibility to nasopharyngeal carcinoma in a Southern Chinese population. Genes Immun.;11(4):334-42. 2010.
  679. Tang,1,2 Minzhong Tao Peng,3 Xiaojiang Gao,4 Li Guan,5 Lisa Maslan,5 Zhiming Liu,3 Lequn Li,3 Minhao Peng,3 Tangwei Liu,3 Yi Zeng,1 Cheryl A. Winkler,5 Mary Carrington,4 and Stephen J. O’Brien2* Genetic Association between HLA Class I Alleles and Hepatitis B Virus-Related Hepatocellular Carcinoma in a Southern Chinese Population.
  680. Driscoll, C.A., Macdonald, D.W., O’Brien, S.J.: From wild animals to domestic pets, an evolutionary view of domestication. Proc Natl Acad Sci U S A. 2009 Jun 16;106 Suppl 1:9971-8..
  681. Klein, G., Klein, E., Klotman, M., Klotman, P., kotler, M., Kurth, R., Lafeuillade, A., La Placa, M., Lewis, J., Lillo, F., Lisziewicz, J., Lomonico, A., Lopalco, L., Lori, F., Lusso, P., Macchi, B., Malim, M., Margolis, L., Markham, P.D., McClure, M., Miller, M., Mingari, M.C., Moretta, L., Noonan, D., O’Brien, S.J., Okamoto, T., Pal, R., Palese, P., Panet, A., Pantaleo, G., Pavalakis, G., Pistello, M., Plotkin, S., Poli, G., Pomerantz, R., Radaelli, A., Guroff, M.R. Roederer, M., Sarngadharan, M.G., Schols, D., Secchiero, P., Shearer, G., Siccardi, A., Stevenson, M., Svoboda, J., Tartaglia, J., Torelli, G., Tornesello, M.L., Tschachler, E., Vaccarezza, M., Vallbracht, A., Van Lunzen, J., Varnier, O., Vicenzi, E., Von Melchner, H., Witz, I., Zagury, D., Zagury, J.F., Zauli, G., and Zipeto, D., Unsung Hero Robert C. Gallo. Science 3234:206, 2009
  682. Luo, S.J., Johnson. W.E., Martelli, P., Zhang, Y.P., Smith, J.L.D., and O’Brien, S.J. Phylogeography and evolutionary history of the Asian leopard cat (Prionailurus bengalensis) inferred from multiple DNA genealogies. In preparation.
  683. Luo, S.J., Johnson. W.E., Martelli, P., Smith, J.L.D., and O’Brien, S.J. Multiple genealogies reveal significant Indochinese-Sundaic faunal transition at the Isthumus of Kra: Evidence from six Asian felid species. PLoS Genetics , Submitted
  684. 684. Brown MA, Munkhtsog B, Troyer JL, Ross S, Sellers R, Fine AE, Swanson WF, Roelke ME, O’Brien SJ. Feline immunodeficiency virus (FIV) in wild Pallas’ cats.Vet Immunol Immunopathol. 2010 Mar 15;134(1-2):90-5.
  685. Sezgin E, Drosdak A, McIntosh C, Kessing B, Lautenberger JA, Goedert JJ, Phair JP, Troyer JL, Smith MW, O’Brien SJ. Examination of disease-based selection, demographic history and population structure in European Y-chromosome haplogroup I. J Hum Genet. 55(9):613-20. 2010.
  686. Narfstrom, K., David, V., Jarret, O., Beatty, J., Barrs, V., Wilkie, D., O’Brien, S., Menotti-Raymond, M.: Retinal degeneration in the Abyssinian and Somali cat (rdAc): correlation between genotype and phenotype and rdAc allele frequency in two continents. Vet Ophthalmol. 2009 Sep-Oct;12(5):285-91.
  687. Menotti-Raymond, M., David, V.A., Pflueger, S., Roelke, M.E., Kehler, J., O’Brien, S.J., Narfstrom, K.: Widespread retinal degenerative disease mutation (rdAc) discovered among a large number of popular cat breeds. Vet J. 2009 Sep 9;]
  688. Mullikin JC, Hansen NF, Shen L, Ebling H, Donahue WF, Tao W, Saranga DJ, Brand A, Rubenfield MJ, Young AC, Cruz P; NISC Comparative Sequencing Program, Driscoll C, David V, Al-Murrani SW, Locniskar MF, Abrahamsen MS, O’Brien SJ, Smith DR, Brockman JA. Light whole genome sequence for SNP discovery across domestic cat breeds.BMC Genomics.;11:406. 2010
  689. O’Brien, S. J. Impressions from NAS Darwin Celebration. 2009. Science. http://blogs.sciencemag.org/cgi-bin/mt/mt-search.cgi?search=Impressions+from+NAS+Darwin+Celebration&IncludeBlogs=7
  690. Eizirik, E., Murphy, W.J., Koepfli, K.P., Johnson, W.E., Dragoo, J.W., Wayne, R.K., O’Brien, S.J.: Pattern and timing of diversification of the mammalian order Carnivora inferred from multiple nuclear gene sequences. Mol Phylogenet Evol. 2010 Jul;56(1):49-63
  691. Fellay, J, Dongliang Ge, Kevin V Shianna, Sara Colombo, Bruno Ledergerber,Elizabeth T Cirulli, Thomas J Urban1, Kunlin Zhang, Curtis E Gumbs, Jason P Smith, Antonella Castagna, Alessandro Cozzi-Lepri, Andrea De Luca, Philippa Easterbrook, jhh Huldrych F Günthard, Simon Mallal, Cristina Mussini, Judith Dalmau, Javier Martinez-Picado, José M Miro, Niels Obel, Steven M Wolinsky, Jeremy J Martinson, RogerDetels, Joseph B Margolick, Lisa P Jacobson, Patrick Descombes, Stylianos EAntonarakis, Jacques S Beckmann, Stephen J O’Brien, Norman L Letvin, Andrew J. McMichael, Barton F Haynes, Mary Carrington, Sheng Feng, Amalio Telenti & David B. Goldstein for the NIAID Center for HIV/AIDS Vaccine Immunology (CHAVI). Common genetic variation and the control of HIV-1 in humans. PLOSGenetics. 2009 Dec;5(12):e1000791. Epub 2009 Dec 24.
  692. Johnson,Warren E., David P. Onorato, Melody E. Roelke, E. Darrell Land, Mark Cunningham, Chris Belden, Roy McBride, Deborah Jansen, Mark Lotz, David Shindle, JoGayle Howard, David E. Wildt, Linda M. Penfold, Jeffrey A. Hostetler, Madan K. Oli, and Stephen J. O’Brien . 2010 Genetic Restoration of the Florida Panther SCIENCE Volume: 329 Issue: 5999 Pages: 1641-1645
  693. Eizirik, E., David, V.A., Buckley-Beason, V., Roelke, M.E., Schaeffer, A.A., Hannah, S.S., Narfstrom, K., O’Brien, S.J., Menotti-Raymond, M.: . Defining and Mapping Mammalian Coat Pattern Genes: Multiple Genomic Regions Implicated in Domestic Cat Stripes and Spots. GENETICS Volume: 184 Issue: 1 Pages: 267-275
  694. Hendrickson SL, Jabs DA, Van Natta M, Lewis RA, Wallace DC, O’Brien SJ. Mitochondrial haplogroups are associated with risk of neuroretinal disorder in HIV-positive patients. J Acquir Immune Defic Syndr. Apr 1;53(4):451-5. 2010.
  695. Menotti-Raymond, M., Deckman, K.H., David, V., Myrkalo, J., O’Brien, S.J., Narfstrom, K.: Mutation discovered in a feline model of human congenital retinal blinding disease. Invest Ophthalmol Vis Sci. 2010 Jun;51(6):2852-9.
  696. Hendrickson, SL, Lautenberger, J, Chinn, L, Phair, J, Goedert, JJ, Vlahov, D, Donfield, S. Buchbinder, SP, Troyer, J, O’Brien, SJ. . Genetic Variants in Nuclear-Encoded Mitochondrial Genes Influence AIDS Progression PLOS ONE Volume: 5 Issue: 9 Article Number: e12862 2010
  697. O’Brien SJ. Comparative genomics in vertebrates: a role for the platypus. Introduction.Reprod Fertil Dev.;21(8):vii-ix. 2009
  698. Sezgin E, Hendrickson SL, Jabs DA, Van Natta ML, Lewis RA, Troyer JL, O’Brien SJ; SOCA Research Group. Effect of host genetics on incidence of HIV neuroretinal disorder in patients with AIDS. J Acquir Immune Defic Syndr.;54(4):343-51. 2010.
  699. Troyer JL, Nelson GW, Lautenberger JA, Chinn L, McIntosh C, Johnson RC, Sezgin E, Kessing B, Malasky M, Hendrickson SL, Li G, Pontius J, Tang M, An P, Winkler CA, Limou S, Le Clerc S, Delaneau O, Zagury JF, Schuitemaker H, van Manen D, Bream JH, Gomperts ED, Buchbinder S, Goedert JJ, Kirk GD, O’Brien SJ. Genome-wide association study implicates PARD3B-based AIDS restriction.J Infect Dis.203(10):1491-502. 2011
  700. Genome 10K Community of Scientists: A Proposal to Obtain Whole-genomeSsequence for 10,000 Vertebrate Species. J Hered. 2009 Nov-Dec;100(6):659-74.
  701. Johnson, R, Nelson, GW, Troyer, JL, Lautenberger, JA, Kessing, BD, Winkler, CA, O’Brien, SJ.. Accounting for multiple comparisons in a genome wide association study (GWAS). BMC Genomics. 11:724 2010
  702. Chinn LW, Tang M, Kessing BD, Lautenberger JA, Troyer JL, Malasky MJ, McIntosh C, Kirk GD, Wolinsky SM, Buchbinder SP, Gomperts ED, Goedert JJ, O’Brien SJ. Genetic associations of variants in genes encoding HIV-dependency factors required for HIV-1 infection. J Infect Dis. 15;202(12):1836-45. 2010.
  703. Driscoll C, Yamaguchi N, O’Brien SJ, Macdonald DW. A Suite of Genetic Markers Useful in Assessing Wildcat (Felis silvestris ssp.)– Domestic Cat (Felis silvestris catus) Admixture. J Hered. 102 Suppl 1:S87-90. 2011.
  704. Sezgin E, van Natta ML, Ahuja A, Lyon A, Srivastava S, Troyer JL, O’Brien SJ, Jabs DA; Studies of the Ocular Complications of AIDS Research Group..Association of host genetic risk factors with the course of cytomegalovirus retinitis in patients infected with human immunodeficiency virus. Am J Ophthalmol. 151(6):999-1006.e4. 2011.
  705. Guo X, Zhang Y, Li J, Ma J, Wei Z, Tan W, O’Brien SJ. Strong influence of human leukocyte antigen (HLA)-DP gene variants on development of persistent chronic hepatitis B virus carriers in the Han Chinese population. Hepatology.;53(2):422-8. 2011.
  706. An P, Winkler C, Guan L, O’Brien SJ, Zeng Z; HBV Study Consortium. A common HLA-DPA1 variant is a major determinant of hepatitis B virus clearance in Han Chinese. J Infect Dis. Apr 1;203(7):943-947. 2011.
  707. Perelman P, Johnson WE, Roos C, Seuánez HN, Horvath JE, Moreira MA, Kessing B, Pontius J, Roelke M, Rumpler Y, Schneider MP, Silva A, O’Brien SJ, Pecon-Slattery J. A molecular phylogeny of living primates. PLoS Genet. Mar;7(3):e1001342. 2011.
  708. Johnson WE, Perelman P, O’Brien SJ. Camelid genomics: Anticipating the future. Jour Camelid Science IN press
  709. da Fonseca RR, Johnson WE, O’Brien SJ, Vasconcelos V, Antunes A. Molecular evolution and the role of oxidative stress in the expansion and functional diversification of cytosolic glutathione transferases BMC EVOLUTIONARY BIOLOGY Volume: 10 Article Number: 281 2010
  710. Guo X, Zeng Y, Deng H, Liao J, Zheng Y, Li J, Kessing B, O’Brien SJ. Genetic Polymorphisms of CYP2E1, GSTP1, NQO1 and MPO and the Risk of Nasopharyngeal Carcinoma in a Han Chinese Population of Southern China BMC Res Notes. 2010 Jul 27;3(1):212.
  711. Driscoll CA, Sanderson E, Christie S, Luo SJ, Seidensticker J, Miquelle D, Goodrich J, Dinerstein E, Shrethsta M, Zhuralev Y, Jhala YV, Yadav SP, Pikunov DG, Darman Y, Breitenmoser U, Chestin I, Jungius H, Yamaguchi N, Pereladova O, Wildt DE, Macdonald DW, O’Brien SJ. A Postulate for Tiger Recovery. Journal of Threatened Taxa In press
  712. Shrestha B, Reed JM, Starks PT, Kaufman GE, Goldstone JV, Roelke ME, O’Brien SJ, Koepfli KP, Frank LG, Court MH. Evolution of a major drug metabolizing enzyme defect in the domestic cat and other Felidae: phylogenetic timing and the role of hypercarnivory. PLoS One.6(3):e18046. 2011.
  713. Sezgin E, Jabs DA, Hendrickson SL, Van Natta M, Zdanov A, Lewis RA, Smith MW, Troyer JL, O’Brien SJ; SOCA Research Group. Effect of host genetics on the development of cytomegalovirus retinitis in patients with AIDS. J Infect Dis.;202(4):606-13. 2010.
  714. Luo SJ, Johnson WE, O’Brien SJ. Applying molecular genetic tools to tiger conservation. Integr Zool.;5(4):351-62. 2010.
  715. Johnson WE, Onorato DP, Roelke ME,and O’Brien SJ. Genetic Future for Florida Panthers SCIENCE Volume: 330 Issue: 6012 Pages: 1744-1744
  716. .ZhengYingying, Li Guan, Stephen J. O’Brien, Zheng Zeng, the HBV study consortium APOBEC3B deletion/insertion polymorphism and hepatocellular carcinoma with hepatitis B virus infection in Chinese Han population Submitted
  717. Alkan, Can, M. Francesca Cardone, Francesca Antonacci1, Stephen J. O’Brien, Oliver A. Ryder, Stefania Purgato, Giuliano Della Valle, Evan E. Eichler, and Mario Ventura . Genome-wide Characterization of Centromeric Satellites from Multiple Mammalian Species .Genome Res. 2011 Jan;21(1):137-45.
  718. GuoXiuchan , Cheryl A. Winkler,Ji Li, Li Guan, Minzhong Tang, Yi Zengand Stephen J. O’Brien Validation of Nasopharyngeal Carcinoma (NPC) Risk Loci from Two Genome-Wide Association Studies in a Large NPC cohort Cancer Research In Press
  719. Menotti-Raymond, Marilyn , Victor A. David, ., Bruce S. Weir, , Stephen J. O’Brien, A Population Genetic Database of Cat Breeds Developed in Coordination with a Domestic Cat STR Multiplex Jour Forensic Sciences In Press
  720. Tang NPC GWAS he Principal Genetic Determinants for Nasopharyngeal Carcinoma in China Involve HLA Class I Antigen Recognition Groove Nature Genetics In Review
  721. Tang et al HLA Class I analysis in a high NPC incident rate region of southern Chinese population Submitted
  722. O’Brien S. J. REDEFINING TIGER SUBSPECIES In Fierce Beauty: Preserving the World of Wild Cats. Mandala Publ. 324 pages
  723. Hostetler JA, Onorato DP, Nichols JD, Johnson WE, Roelke ME, O’Brien SJ, Jansen D, Oli MK. Genetic Introgression and the Survival of Florida Panther Kittens.Biol Conserv.;143(11):2789-2796. 2010.
  724. Troyer JL, Roelke ME, Jespersen JM, Baggett N, Buckley-Beason V, Macnulty D, Craft M, Packer C, Pecon-Slattery J, O’Brien SJ. FIV diversity: FIV(Ple) subtype composition may influence disease outcome in African lions. Vet Immunol Immunopathol. 143(3-4):338-46. 2011.
  725. Driscoll CA, Luo S, MacDonald D, Dinerstein E, Chestin I, Pereladova O, O’Brien SJ. Restoring tigers to the Caspian region. Science. 333(6044):822-3. 2011.
  726. Moore Andy, Christiaan and Hanli Winterbach , Fenton (Woody) Cotterill , And Stephen O’Brien EVIDENCE FOR ANCESTRAL WETLAND LIONS AND EVOLUTION OF HABITAT SPECIALIZATION DRIVEN BY CLIMATIC AND GEOMORPHIC IMPERATIVES In preparation
  727. Wester, W. C. Svetlana K. Eden3, Bryan E. Shepherd3,Hermann Bussmann1-2,Vladimir Novitsky1 -2, David C. Samuels5, Sher L. Hendrickson6, Cheryl A. Winkler6, Stephen J. O’Brien6, Max Essex1-2, Richard T. D’Aquila3, Victor deGruttola2, and Richard G. Marlink1-2. Combination Antiretroviral Therapy-Treated Females Having a Higher Baseline Body Mass Index Are at Increased Risk for the Development of Moderate-Severe Symptomatic Hyperlactatemia and Lactic Acidosis: Results From a Clinical Trial in Botswana.
  728. Hostetler JA, Onorato DP, Bolker BM, Johnson WE, O’Brien SJ, Jansen D, Oli MK. Does genetic introgression improve female reproductive performance? A test on the endangered Florida panther.Oecologia. In press 2011 .
  729. Katrina M. Morris1#, Katherine Kirby1#, Sonia Cattley2, Victor David3, Vanessa R. Barrs1, Naoya Yukhi4, Stephen J. O’Brien3, Marilyn Menotti-Raymond3, Julia A Beatty1, Katherine Belov1* Development of MHC-linked microsatellite markers in the domestic cat and their use to evaluate MHC diversity in Australian cats, cheetahs and Gir lions. Submited
  730. Kaelin, Christopher B. Xiao Xu, Lewis Z. Hong, Victor A. David, Kelly A., McGowan, Anne Schmidt-Küntzel, Melody E. Roelke, Joan Pontius, Gregory M., Cooper, Hermogenes Manuel Laurie Marker, Cindy K. Harper, Ann van Dyk, Bisong Yue4, James C. Mullikin, Wesley C. Warren, Eduardo Eizirik, Stephen J. O’Brien, Gregory S. Barsh, and Marilyn Menotti-Raymond. Specifying and sustaining pigmentation patterns in domestic and wild cats Submitted.
  731. Wong1,2, Pamela B.Y. Edward O. Wiley3, Warren E. Johnson3, Polina Perelman4Ya-ping Zhang6,7, and Robert W. Murphy1,2,6* Tissue sampling and standards for vertebrate genomics
  732. Hendrickson, SL, O’Brien SJ, Nelson GW. Decorrelating association statistics for diseases with rich clinical data. In preparation.
  733. Mu-Yeong Lee, Jee Yun Hyun, Seo-Jin Lee, Junghwa An, Eunok Lee,Mi-Sook Min, Junpei Kimura, Shin-ichiro Kawada, Nozomi Kurihara, Shu-Jin Luo, Stephen J. O’Brien, Warren E. Johnson, Hang Lee.
    Subspecific Status of the Korean Tiger Inferred by Ancient DNA Analysis